Biomaterial Database

Connections between the zona incerta of the dog diencephalon and the substantia nigra, ventral tegmental field, and pedunculopontine tegmental nucleus. 2010

A I Gorbachevskaya

Laboratory for the Physiology of Higher Nervous Activity, Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia. aig@infran.ru

Studies using technique based on retrograde and anterograde transport of horseradish peroxidase were performed to address the organization of the connections of different sectors of the zone incerta (ZI) of the diencephalon with substructures of the substantia nigra, ventral tegmental field, and pedunculopontine nucleus of the midbrain in dogs. These structures were found to be interconnected. The organization of these connections included elements demonstrating that segregated conduction of functionally diverse information can be transmitted via these pathways. In addition, the convergence of projections fibers from neurons in substructures of the midbrain nucleus described in all sectors of the ZI and to these neurons from neurons in all ZI sectors is evidence that functionally diverse information can be integrated both at the level of the ZI and at the level of the midbrain structures studied here.

UI	MeSH Term	Description	Entries
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013378	Substantia Nigra	The black substance in the ventral midbrain or the nucleus of cells containing the black substance. These cells produce DOPAMINE, an important neurotransmitter in regulation of the sensorimotor system and mood. The dark colored MELANIN is a by-product of dopamine synthesis.	Nigra, Substantia,Nigras, Substantia,Substantia Nigras
D017557	Ventral Tegmental Area	A region in the MESENCEPHALON which is dorsomedial to the SUBSTANTIA NIGRA and ventral to the RED NUCLEUS. The mesocortical and mesolimbic dopaminergic systems originate here, including an important projection to the NUCLEUS ACCUMBENS. Overactivity of the cells in this area has been suspected to contribute to the positive symptoms of SCHIZOPHRENIA.	Area Tegmentalis Ventralis,Ventral Tegmental Area of Tsai,Area Tegmentalis Ventrali,Tegmental Area, Ventral,Tegmentalis Ventrali, Area,Tegmentalis Ventralis, Area
D045042	Pedunculopontine Tegmental Nucleus	Dense collection of cells in the caudal pontomesencephalic tegmentum known to play a role in the functional organization of the BASAL GANGLIA and in the modulation of the thalamocortical neuronal system.	Nucleus Tegmentalis Pedunculopontinus,Nucleus, Pedunculopontine Tegmental,Tegmental Nucleus, Pedunculopontine
D020530	Subthalamus	A transition zone in the anterior part of the diencephalon interposed between the thalamus, hypothalamus, and tegmentum of the mesencephalon. Components of the subthalamus include the SUBTHALAMIC NUCLEUS, zona incerta, nucleus of field H, and the nucleus of ansa lenticularis. The latter contains the ENTOPEDUNCULAR NUCLEUS.	Nucleus of Ansa Lenticularis,Nucleus of Field H,Fasciculus Thalamicus,Field H1 of Forel,Forel's Field H1,Forel's Field H2,Lenticular Fasciculus,Nucleus Campi Foreli,Thalamic Fasciculus,Ansa Lenticularis Nucleus,Campi Foreli, Nucleus,Campi Forelus, Nucleus,Fasciculus, Lenticular,Fasciculus, Thalamic,Field H Nucleus,Field H1, Forel's,Field H2, Forel's,Forel Field H1,Forel Field H2,Foreli, Nucleus Campi,Forels Field H1,Forels Field H2,Forelus, Nucleus Campi,Nucleus Campi Forelus,Thalamicus, Fasciculus