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Interleukin-1 (IL-1)-producing cells in inflamed gingival tissues obtained from patients with periodontitis were examined by combined immunohistochemistry and in situ hybridization. Macrophages, T cells, B cells, and endothelial cells were visualized in the lesions by the immunoperoxidase method using specific antibodies to each cell type. Subsequent in situ hybridization using 35S-labeled synthetic oligonucleotide probes complementary to human IL-1 alpha and IL-1 beta mRNA showed IL-1 transcripts in macrophages predominantly but not in T cells or B cells. Neither fibroblasts nor keratinocytes contained the IL-1 message to any significant extent. Endothelial cells also were essentially negative for IL-1 messages. These findings indicate that IL-1 is produced principally by macrophages in inflamed gingival tissues of humans.
Y Matsuki, and
T Yamamoto, and
K Hara
December 1989,
Nihon Shishubyo Gakkai kaishi,
Y Matsuki, and
T Yamamoto, and
K Hara
April 1995,
Archives of oral biology,
Y Matsuki, and
T Yamamoto, and
K Hara
November 1993,
Infection and immunity,
Y Matsuki, and
T Yamamoto, and
K Hara
November 1999,
Journal of periodontology,
Y Matsuki, and
T Yamamoto, and
K Hara
October 1995,
Archives of oral biology,
Y Matsuki, and
T Yamamoto, and
K Hara
January 1966,
Periodontics,
Y Matsuki, and
T Yamamoto, and
K Hara
July 1997,
Journal of periodontal research,
Y Matsuki, and
T Yamamoto, and
K Hara
September 1989,
Nihon Shishubyo Gakkai kaishi,
Y Matsuki, and
T Yamamoto, and
K Hara
January 1969,
Odontologisk revy,
Y Matsuki, and
T Yamamoto, and
K Hara
July 1989,
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology,
