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We investigated the intensiveness of the cell proliferation, number of mononuclear leucocytes (MNL) and production of interleukin-1 (IL-1) in glomerular cell cultures of rats with nephrotoxic serum (NTS) nephritis and control (C) rats. Five days after intravenous injection of nephrotoxic serum from rabbits the glomeruli were isolated, treated with collagenase and cultured over a period of 20 days. In cultures the number and intensity of mesangial cell proliferation in the NTS group were significantly higher than in the C group. Thus, the intensive mesangial cell proliferation in experimental nephrotoxic serum nephritis is related to infiltration of glomerulus by MNL of bone marrow origin with increased production of IL-1.
O V Gabrilevskaia, and
O P Gladkikh, and
A A Ivanov, and
V P Leskov, and
N V Nikiforova, and
E M Shilov, and
I E Tareeva, and
M A Pal'tsev, and
V I Kirpatovskiĭ
January 1991,
Nephron,
O V Gabrilevskaia, and
O P Gladkikh, and
A A Ivanov, and
V P Leskov, and
N V Nikiforova, and
E M Shilov, and
I E Tareeva, and
M A Pal'tsev, and
V I Kirpatovskiĭ
January 1990,
American journal of nephrology,
O V Gabrilevskaia, and
O P Gladkikh, and
A A Ivanov, and
V P Leskov, and
N V Nikiforova, and
E M Shilov, and
I E Tareeva, and
M A Pal'tsev, and
V I Kirpatovskiĭ
January 1989,
American journal of nephrology,
O V Gabrilevskaia, and
O P Gladkikh, and
A A Ivanov, and
V P Leskov, and
N V Nikiforova, and
E M Shilov, and
I E Tareeva, and
M A Pal'tsev, and
V I Kirpatovskiĭ
November 1988,
International journal of cancer,
O V Gabrilevskaia, and
O P Gladkikh, and
A A Ivanov, and
V P Leskov, and
N V Nikiforova, and
E M Shilov, and
I E Tareeva, and
M A Pal'tsev, and
V I Kirpatovskiĭ
January 1988,
International archives of allergy and applied immunology,
O V Gabrilevskaia, and
O P Gladkikh, and
A A Ivanov, and
V P Leskov, and
N V Nikiforova, and
E M Shilov, and
I E Tareeva, and
M A Pal'tsev, and
V I Kirpatovskiĭ
April 1993,
Laboratory investigation; a journal of technical methods and pathology,
O V Gabrilevskaia, and
O P Gladkikh, and
A A Ivanov, and
V P Leskov, and
N V Nikiforova, and
E M Shilov, and
I E Tareeva, and
M A Pal'tsev, and
V I Kirpatovskiĭ
January 1989,
Clinical and experimental immunology,
O V Gabrilevskaia, and
O P Gladkikh, and
A A Ivanov, and
V P Leskov, and
N V Nikiforova, and
E M Shilov, and
I E Tareeva, and
M A Pal'tsev, and
V I Kirpatovskiĭ
July 1988,
Cellular immunology,
O V Gabrilevskaia, and
O P Gladkikh, and
A A Ivanov, and
V P Leskov, and
N V Nikiforova, and
E M Shilov, and
I E Tareeva, and
M A Pal'tsev, and
V I Kirpatovskiĭ
May 1985,
Clinical and experimental immunology,
O V Gabrilevskaia, and
O P Gladkikh, and
A A Ivanov, and
V P Leskov, and
N V Nikiforova, and
E M Shilov, and
I E Tareeva, and
M A Pal'tsev, and
V I Kirpatovskiĭ
July 1997,
The American journal of pathology,
