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STUDY OBJECTIVE - The aim was to investigate whether heterogeneous coronary blood flow is maldistributed during endotoxin shock. DESIGN - Variables were studied before (t = 0) and at t = 90 and t = 120 min after bolus injection of saline (n = 6) or endotoxin (n = 6). SUBJECTS - 12 anaesthetised mongrel dogs, weight 20-27 kg, were used. MEASUREMENTS AND MAIN RESULTS - We studied myocardial blood flows in small tissue sections (of about 1 g in left and 2 g in right ventricle) with radioactive microspheres, together with haemodynamic variables and global myocardial metabolism. At t = 0 min in controls, regional flows per 100 g were heterogeneous and ranged from a factor 0.2 to 2.7 and 0.6 to 1.6 of mean flow per 100 g to the left and right ventricle respectively; heterogeneity was unchanged at t = 90 and t = 120 min. Between t = 0, t = 90, and t = 120 min regional flows correlated: r = 0.78(SD 0.14), n = 18, for left ventricle, and r = 0.70(0.17) for right ventricle. In the endotoxin group, cardiac output and mean arterial pressure decreased by 44(7) and 48(11)% respectively, and lactate increased by 3.2(0.6) mmol.litre-1 at t = 120 min. Global left ventricle blood flow and delivery and metabolism of O2 were unchanged; lactate extraction and external work fell. The ratio between global right ventricular O2 delivery and external work also rose. Regional blood flows ranged from a factor 0.2 to 2.7 and 0.1 to 1.8 of mean flow to left and right ventricles respectively; heterogeneity did not differ from controls and did not change with time. Flow correlations with time were reduced: 0.45(0.24) for left ventricle and 0.45(0.26) for right ventricle (both n = 18, p less than 0.005 v controls). The left ventricular endocardial to epicardial flow ratio fell; flow was redistributed to both layers. CONCLUSIONS - Heterogeneous blood flow is redistributed throughout the heart during canine endotoxin shock so that, at unchanged global blood flow and flow heterogeneity, flow decreases in some but increases in other areas. Flow maldistribution may be associated with focal ischaemia, which may be masked by a rise in O2 uptake for a given workload (contractile inefficiency) in overperfused areas, and may thereby contribute to a fall in global myocardial external work for a given O2 delivery.
A B Groeneveld, and
A A van Lambalgen, and
G C van den Bos, and
W Bronsveld, and
J J Nauta, and
L G Thijs
January 1987,
Circulatory shock,
A B Groeneveld, and
A A van Lambalgen, and
G C van den Bos, and
W Bronsveld, and
J J Nauta, and
L G Thijs
January 1978,
Surgical forum,
A B Groeneveld, and
A A van Lambalgen, and
G C van den Bos, and
W Bronsveld, and
J J Nauta, and
L G Thijs
July 1970,
Masui. The Japanese journal of anesthesiology,
A B Groeneveld, and
A A van Lambalgen, and
G C van den Bos, and
W Bronsveld, and
J J Nauta, and
L G Thijs
July 1973,
Surgery, gynecology & obstetrics,
A B Groeneveld, and
A A van Lambalgen, and
G C van den Bos, and
W Bronsveld, and
J J Nauta, and
L G Thijs
January 1980,
Circulatory shock,
A B Groeneveld, and
A A van Lambalgen, and
G C van den Bos, and
W Bronsveld, and
J J Nauta, and
L G Thijs
February 1986,
The American review of respiratory disease,
A B Groeneveld, and
A A van Lambalgen, and
G C van den Bos, and
W Bronsveld, and
J J Nauta, and
L G Thijs
April 1980,
Acta physiologica Scandinavica,
A B Groeneveld, and
A A van Lambalgen, and
G C van den Bos, and
W Bronsveld, and
J J Nauta, and
L G Thijs
January 1986,
Circulatory shock,
A B Groeneveld, and
A A van Lambalgen, and
G C van den Bos, and
W Bronsveld, and
J J Nauta, and
L G Thijs
February 1987,
The American journal of physiology,
A B Groeneveld, and
A A van Lambalgen, and
G C van den Bos, and
W Bronsveld, and
J J Nauta, and
L G Thijs
January 1978,
Scandinavian journal of immunology,
