Primary progressive non-fluent aphasia: a case study. 1991

L D Kartsounis, and R F Crellin, and H Crewes, and B K Toone
National Hospital for Nervous Diseases, London.

A case study of a 65 year old man is described with an eight-year history of progressive primary non-fluent aphasia accompanied by agrammatism, phonemic paraphasias and mild spelling dysgraphia. His naming ability, however, has remained at an exceptionally high level and there has been no evidence of impairment of word or sentence comprehension. Non-verbal skills and memory functions have also been preserved within the range of his very high premorbid level of abilities. Single photon emission computed tomography was consistent with bifrontal hypoperfusion. We argue that the selective language deficits in this patient are characteristic of dynamic aphasia and of other speech disturbances which are also known to be associated with left frontal lesions. The possible underlying pathology is discussed in the context of known degenerative disorders.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009483 Neuropsychological Tests Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury. Aphasia Tests,Cognitive Test,Cognitive Testing,Cognitive Tests,Memory for Designs Test,Neuropsychological Testing,AX-CPT,Behavioral Assessment of Dysexecutive Syndrome,CANTAB,Cambridge Neuropsychological Test Automated Battery,Clock Test,Cognitive Function Scanner,Continuous Performance Task,Controlled Oral Word Association Test,Delis-Kaplan Executive Function System,Developmental Neuropsychological Assessment,Hooper Visual Organization Test,NEPSY,Neuropsychologic Tests,Neuropsychological Test,Paced Auditory Serial Addition Test,Repeatable Battery for the Assessment of Neuropsychological Status,Rey-Osterrieth Complex Figure,Symbol Digit Modalities Test,Test of Everyday Attention,Test, Neuropsychological,Tests, Neuropsychological,Tower of London Test,Neuropsychologic Test,Test, Cognitive,Testing, Cognitive,Testing, Neuropsychological,Tests, Cognitive
D012039 Regional Blood Flow The flow of BLOOD through or around an organ or region of the body. Blood Flow, Regional,Blood Flows, Regional,Flow, Regional Blood,Flows, Regional Blood,Regional Blood Flows
D002540 Cerebral Cortex The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulci. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions. Allocortex,Archipallium,Cortex Cerebri,Cortical Plate,Paleocortex,Periallocortex,Allocortices,Archipalliums,Cerebral Cortices,Cortex Cerebrus,Cortex, Cerebral,Cortical Plates,Paleocortices,Periallocortices,Plate, Cortical
D005500 Follow-Up Studies Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease. Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D005625 Frontal Lobe The part of the cerebral hemisphere anterior to the central sulcus, and anterior and superior to the lateral sulcus. Brodmann Area 8,Brodmann's Area 8,Frontal Cortex,Frontal Eye Fields,Lobus Frontalis,Supplementary Eye Field,Area 8, Brodmann,Area 8, Brodmann's,Brodmanns Area 8,Cortex, Frontal,Eye Field, Frontal,Eye Field, Supplementary,Eye Fields, Frontal,Frontal Cortices,Frontal Eye Field,Frontal Lobes,Lobe, Frontal,Supplementary Eye Fields
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000377 Agnosia Loss of the ability to comprehend the meaning or recognize the importance of various forms of stimulation that cannot be attributed to impairment of a primary sensory modality. Tactile agnosia is characterized by an inability to perceive the shape and nature of an object by touch alone, despite unimpaired sensation to light touch, position, and other primary sensory modalities. Auditory Agnosia,Finger Agnosia,Sensory Agnosia,Tactile Agnosia,Visual Agnosia,Agnosia for Pain,Agnosia for Smell,Agnosia for Taste,Agnosia for Temperature,Anosognosia,Auditory Agnosia, Congenital,Body-Image Agnosia,Congenital Auditory Agnosia,Developmental Agnosia,Gustatory Agnosia,Ideational Agnosia,Olfactory Agnosia,Position Agnosia,Somatosensory Agnosia,Time Agnosia,Topographical Agnosia,Visual Agnosia for Objects,Visual Disorientation Syndrome,Visuospatial Agnosia,Agnosia for Tastes,Agnosia, Auditory,Agnosia, Body-Image,Agnosia, Congenital Auditory,Agnosia, Developmental,Agnosia, Finger,Agnosia, Gustatory,Agnosia, Ideational,Agnosia, Olfactory,Agnosia, Position,Agnosia, Sensory,Agnosia, Somatosensory,Agnosia, Tactile,Agnosia, Time,Agnosia, Topographical,Agnosia, Visual,Agnosia, Visuospatial,Agnosias,Agnosias, Auditory,Agnosias, Body-Image,Agnosias, Congenital Auditory,Agnosias, Developmental,Agnosias, Finger,Agnosias, Ideational,Agnosias, Olfactory,Agnosias, Position,Agnosias, Sensory,Agnosias, Somatosensory,Agnosias, Tactile,Agnosias, Time,Agnosias, Topographical,Agnosias, Visual,Agnosias, Visuospatial,Anosognosias,Auditory Agnosias,Auditory Agnosias, Congenital,Body Image Agnosia,Body-Image Agnosias,Congenital Auditory Agnosias,Developmental Agnosias,Finger Agnosias,Ideational Agnosias,Olfactory Agnosias,Position Agnosias,Sensory Agnosias,Somatosensory Agnosias,Syndrome, Visual Disorientation,Syndromes, Visual Disorientation,Tactile Agnosias,Time Agnosias,Topographical Agnosias,Visual Agnosias,Visual Disorientation Syndromes,Visuospatial Agnosias
D001039 Aphasia, Broca An aphasia characterized by impairment of expressive LANGUAGE (speech, writing, signs) and relative preservation of receptive language abilities (i.e., comprehension). This condition is caused by lesions of the motor association cortex in the FRONTAL LOBE (BROCA AREA and adjacent cortical and white matter regions). Agrammatism,Aphasia, Motor,Aphasia, Nonfluent,Broca Aphasia,Dysphasia, Broca,Agrammatic Broca Aphasia,Agrammatic Broca's Aphasia,Aphasia, Anterior,Aphasia, Ataxic,Aphasia, Expressive,Aphasia, Frontocortical,Dysphasia, Broca's,Verbal Aphasia Syndrome,Agrammatic Broca Aphasias,Agrammatic Broca's Aphasias,Agrammatic Brocas Aphasia,Anterior Aphasia,Anterior Aphasias,Aphasia Syndrome, Verbal,Aphasia Syndromes, Verbal,Aphasia, Agrammatic Broca,Aphasia, Agrammatic Broca's,Aphasias, Agrammatic Broca,Aphasias, Agrammatic Broca's,Aphasias, Anterior,Aphasias, Ataxic,Aphasias, Broca,Aphasias, Frontocortical,Ataxic Aphasia,Ataxic Aphasias,Broca Aphasia, Agrammatic,Broca Aphasias,Broca Aphasias, Agrammatic,Broca Dysphasia,Broca's Aphasia, Agrammatic,Broca's Aphasias, Agrammatic,Broca's Dysphasia,Dysphasia, Brocas,Expressive Aphasia,Frontocortical Aphasia,Frontocortical Aphasias,Motor Aphasia,Nonfluent Aphasia,Syndrome, Verbal Aphasia,Syndromes, Verbal Aphasia,Verbal Aphasia Syndromes

Related Publications

L D Kartsounis, and R F Crellin, and H Crewes, and B K Toone
January 2004, Nihon rinsho. Japanese journal of clinical medicine,
L D Kartsounis, and R F Crellin, and H Crewes, and B K Toone
April 1993, No to shinkei = Brain and nerve,
L D Kartsounis, and R F Crellin, and H Crewes, and B K Toone
January 2001, Neurocase,
L D Kartsounis, and R F Crellin, and H Crewes, and B K Toone
June 2016, Dementia and neurocognitive disorders,
L D Kartsounis, and R F Crellin, and H Crewes, and B K Toone
January 2023, Rinsho shinkeigaku = Clinical neurology,
L D Kartsounis, and R F Crellin, and H Crewes, and B K Toone
November 2003, Revue neurologique,
L D Kartsounis, and R F Crellin, and H Crewes, and B K Toone
January 2007, Behavioural neurology,
L D Kartsounis, and R F Crellin, and H Crewes, and B K Toone
June 2012, The Lancet. Neurology,
L D Kartsounis, and R F Crellin, and H Crewes, and B K Toone
January 1996, Annals of the New York Academy of Sciences,
L D Kartsounis, and R F Crellin, and H Crewes, and B K Toone
March 2014, Journal of neurology, neurosurgery, and psychiatry,
Copied contents to your clipboard!