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Thrombospondin production and thrombospondin-mediated adhesion in U937 cells. 1991
J Varani, and
L Stoolman, and
T Wang, and
L Schuger, and
C Flippen, and
M Dame, and
K J Johnson, and
R F Todd, and
U S Ryan, and
P A Ward
Department of Pathology, University of Michigan Medical School, Ann Arbor 48109.
U937 cells have low levels of surface thrombospondin (TSP) under control conditions but express higher levels after treatment for 1 day with 100 nM phorbol myristate acetate (PMA). Increased surface expression is due, in part, to increased biosynthesis. Untreated U937 cells do not adhere to TSP-coated plastic culture dishes but adhere strongly to TSP after stimulation with PMA. Untreated U937 cells also adhere weakly to endothelial cell monolayers while PMA-treated U937 cells attach strongly to monolayers of rat pulmonary artery endothelial cells. Endothelial cell adhesion appears to be mediated, in part, by TSP since antibodies to TSP partially inhibit.
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