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Anti-osteoporotic constituents from Indian medicinal plants. 2010
Manmeet Kumar, and
Preeti Rawat, and
Preeti Dixit, and
Devendra Mishra, and
Abnish K Gautam, and
Rashmi Pandey, and
Divya Singh, and
Naibedya Chattopadhyay, and
Rakesh Maurya
Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR, M. G. Road, Lucknow 226001, Uttar Pradesh, India.
The objective of this study was to determine the in vitro osteogenic activities of selected medicinal plants used traditionally in India. The compounds isolated from three plants viz. Allophylus serratus, Cissus quadrangularis and Vitex negundo were evaluated for their in vitro osteogenic activities. Primary cultures of osteoblasts were used to determine the effects of these components on osteoblast functions. Five of the fourteen compounds isolated led to increase in osteoblast differentiation and mineralization. These findings lend support to the use of Allophylus serratus, Cissus quadrangularis and Vitex negundo in traditional medicine.
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