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Anti-inflammatory treatment with pentoxifylline improves HIV-related endothelial dysfunction: a pilot study. 2010
Samir K Gupta, and
Raymond M Johnson, and
Kieren J Mather, and
Matthias Clauss, and
Jalees Rehman, and
Chandan Saha, and
Zeruesenay Desta, and
Michael P Dubé
Department of Medicine, Indiana Center for Vascular Biology and Medicine, Indiana University School of Medicine, Indianapolis, USA. sgupta1@iupui.edu <sgupta1@iupui.edu>
We performed a single-arm, open-label pilot trial of the anti-inflammatory drug pentoxifylline to reduce systemic inflammation and improve endothelial function, measured by flow-mediated dilation of the brachial artery, in HIV-infected patients not requiring antiretroviral therapy. Pentoxifylline significantly reduced circulating levels of vascular cell adhesion molecule-1 and interferon-gamma-induced protein and significantly improved endothelial function during the 8-week trial. Pentoxifylline may reverse HIV-related endothelial dysfunction by directly inhibiting the endothelial leukocyte adhesion pathway.
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