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Enhanced resection and improved survival in murine neuroblastoma (C1300-NB) after preoperative immunotherapy. 1991
C L Fowler, and
S P Brooks, and
R Squire, and
G A Rich, and
J E Rossman, and
M J Finegold, and
J E Allen, and
D R Cooney
Department of Surgery, School of Medicine and Biomedical Sciences, State University of New York, Buffalo.
Advanced neuroblastoma treated with standard chemotherapy has a poor prognosis. Combination immunotherapy for murine neuroblastoma with retinyl palmitate, low-dose cyclophosphamide, and interleukin-2 resulted in increased survival, impaired tumor growth, easier surgical resection, and increased class I expression or tumor cells. Preoperative immunotherapy may be useful in treatment of advanced human neuroblastoma.
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