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In vitro effect of sulfamethoxazole-trimethoprim against Histoplasma capsulatum var. capsulatum. 2010
Raimunda Sâmia Nogueira Brilhante, and
Maria Auxiliadora Bezerra Fechine, and
Rossana de Aguiar Cordeiro, and
Marcos Fábio Gadelha Rocha, and
Joyce Fonteles Ribeiro, and
André Jalles Monteiro, and
Rita Amanda Chaves de Lima, and
Jacó Ricarte Lima Mesquita, and
Zoilo Pires de Camargo, and
José Júlio Costa Sidrim
Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Federal University of Ceará, Fortaleza, Ceará, Brazil. brilhante@ufc.br
This study evaluated the in vitro effect of sulfamethoxazole-trimethoprim against Histoplasma capsulatum var. capsulatum isolated from HIV-positive patients. The drugs were tested by microdilution testing in accordance with the CLSI guidelines. All of the strains were inhibited by sulfamethoxazole-trimethoprim, with MIC ranges of 0.039 (sulfamethoxazole)/0.0078 (trimethoprim) mg/ml to 0.625/0.125 mg/ml for mycelial forms and 0.0025/0.0005 to 0.02/0.004 mg/ml for yeast-like forms. However, in vivo studies are necessary to evaluate the significance of these results.
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