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Pancreatic insulitis and diabetes mellitus were induced in Charles River CD-1 mice with five subdiabetogenic injections of streptozotocin. Plasma glucose and immunoreactive insulin levels were measured and animals were sacrificed at intervals for morphologic studies of pancreatic islets and measurements of extractable pancreatic immunoreactive insulin. Light microscopy revealed striking insulitis, 5 to 6 days after streptozotocin injections, with cell necrosis and eventual islet atrophy due to beta-cell necrosis, and numerous type C viruses within many of the surviving beta-cells. Light microscopic immunoperoxidase stains of islet cell hormones and electron microscopy identified relatively increased numbers of alpha- and delta-cells within the atrophic islets 6 and 12 months after streptozotocin injections. Plasma glucose, plasma immunoreactive insulin, and extractable pancreatic immunoreactive insulin measurements documented the persistence of profound hyperglycemia, as well as the reduction of plasma and pancreatic immunoreactive insulin levels. Immunofluorescence studies demonstrated the absence of circulating islet cell antibodies during both the acute and chronic stages of the syndrome. The pathogenesis of this model of insulin-deficient diabetes is believed to be a cell-mediated autoimmune reaction directed against pancreatic beta-cells altered by subdiabetogenic injections of streptozotocin. The importance of the increased number of type C viruses within surviving beta-cells remains obscure.
A A Like, and
M C Appel, and
R M Williams, and
A A Rossini
July 1976,
Science (New York, N.Y.),
A A Like, and
M C Appel, and
R M Williams, and
A A Rossini
January 1984,
Biomedica biochimica acta,
A A Like, and
M C Appel, and
R M Williams, and
A A Rossini
April 1983,
Brain research,
A A Like, and
M C Appel, and
R M Williams, and
A A Rossini
January 1978,
Verhandlungen der Deutschen Gesellschaft fur Pathologie,
A A Like, and
M C Appel, and
R M Williams, and
A A Rossini
November 1999,
Diabetes research and clinical practice,
A A Like, and
M C Appel, and
R M Williams, and
A A Rossini
February 1981,
Clinical and experimental immunology,
A A Like, and
M C Appel, and
R M Williams, and
A A Rossini
May 1999,
Diabetes research and clinical practice,
A A Like, and
M C Appel, and
R M Williams, and
A A Rossini
March 1979,
Lancet (London, England),
A A Like, and
M C Appel, and
R M Williams, and
A A Rossini
September 1994,
The American journal of pathology,
A A Like, and
M C Appel, and
R M Williams, and
A A Rossini
July 1999,
Clinical and experimental immunology,
