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These studies evaluated the antimuscarinic activity of bornaprine hydrochloride, a synthetic anticholinergic drug utilized in the treatment of parkinsonism. Several of its metabolites were also evaluated. Biological activity was assessed by the ability of the compounds to inhibit the negative inotropic response to carbachol in the isolated left atrium of the rat. Bornaprine showed a pA2 value (concentration required to reduce the agonist response by 50%) of 7.27 +/- 0.21. The exo and endo epimers were approximately equipotent in this regard. One metabolite, the 5-hydroxyl, showed similar activity to the parent compound, whereas 2 other hydroxylated metabolites showed much less effect.
C D Hufford, and
S A Elmarakby, and
L A Walker
January 1973,
Acta pharmacologica et toxicologica,
C D Hufford, and
S A Elmarakby, and
L A Walker
December 1976,
European journal of pharmacology,
C D Hufford, and
S A Elmarakby, and
L A Walker
January 1979,
Pharmacology,
C D Hufford, and
S A Elmarakby, and
L A Walker
January 1990,
Die Pharmazie,
C D Hufford, and
S A Elmarakby, and
L A Walker
January 2005,
Medicina (Kaunas, Lithuania),
C D Hufford, and
S A Elmarakby, and
L A Walker
January 2007,
Medicina (Kaunas, Lithuania),
C D Hufford, and
S A Elmarakby, and
L A Walker
August 1993,
Journal of the American Society of Nephrology : JASN,
C D Hufford, and
S A Elmarakby, and
L A Walker
February 1989,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
C D Hufford, and
S A Elmarakby, and
L A Walker
January 1976,
The Journal of physiology,
C D Hufford, and
S A Elmarakby, and
L A Walker
December 2000,
Toxicology,
