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The effects of hyposalivation on the induction of dental caries and on the oral microflora were examined in SPF Sprague-Dawley rats with or without inoculation of oral streptococci. Significant dental caries was induced in hyposalivated rats, irrespective of the infection with oral streptococci including Streptococcus mutans. In addition, bacteriological analyses demonstrated that the total number of lactobacilli increased significantly at the expense of the inoculated streptococci. These findings suggest that opportunistic infections may be induced in the oral cavity of hyposalivated rats and some acidogenic microorganisms including lactobacilli may promote the induction of dental caries.
T Ooshima, and
T Hashida, and
H Fuchihata, and
T Fujiwara, and
T Yoshida, and
A Izumitani, and
S Sobue, and
S Hamada
April 2005,
Homeopathy : the journal of the Faculty of Homeopathy,
T Ooshima, and
T Hashida, and
H Fuchihata, and
T Fujiwara, and
T Yoshida, and
A Izumitani, and
S Sobue, and
S Hamada
January 1966,
Archives of oral biology,
T Ooshima, and
T Hashida, and
H Fuchihata, and
T Fujiwara, and
T Yoshida, and
A Izumitani, and
S Sobue, and
S Hamada
January 1967,
Nature,
T Ooshima, and
T Hashida, and
H Fuchihata, and
T Fujiwara, and
T Yoshida, and
A Izumitani, and
S Sobue, and
S Hamada
February 1951,
The Journal of nutrition,
T Ooshima, and
T Hashida, and
H Fuchihata, and
T Fujiwara, and
T Yoshida, and
A Izumitani, and
S Sobue, and
S Hamada
December 1970,
Archives of oral biology,
T Ooshima, and
T Hashida, and
H Fuchihata, and
T Fujiwara, and
T Yoshida, and
A Izumitani, and
S Sobue, and
S Hamada
January 1954,
Stomatologiia,
T Ooshima, and
T Hashida, and
H Fuchihata, and
T Fujiwara, and
T Yoshida, and
A Izumitani, and
S Sobue, and
S Hamada
December 1990,
Oral microbiology and immunology,
T Ooshima, and
T Hashida, and
H Fuchihata, and
T Fujiwara, and
T Yoshida, and
A Izumitani, and
S Sobue, and
S Hamada
January 1973,
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
T Ooshima, and
T Hashida, and
H Fuchihata, and
T Fujiwara, and
T Yoshida, and
A Izumitani, and
S Sobue, and
S Hamada
October 1979,
Jikken dobutsu. Experimental animals,
T Ooshima, and
T Hashida, and
H Fuchihata, and
T Fujiwara, and
T Yoshida, and
A Izumitani, and
S Sobue, and
S Hamada
January 1988,
Microbiology and immunology,
