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The mutagenic potential of acrolein has been studied with a wide range of in vitro and in vivo genetic toxicity assays. The data often have been conflicting, especially with the Ames assay. This study was undertaken to assess the mutagenic potential of acrolein using the CHO/HGPRT assay, both with and without metabolic activation. This assay system was chosen because it provides eukaryotic DNA as the target and is capable of detecting a range of mutational events. Because of its considerable toxicity, acrolein was tested over a very narrow dose range of 0.2-2 nl ml-1 without exogenous activation and 0.5-8 nl ml-1 with rat S-9 activation. Multiple assays were performed under both conditions. The results indicated that while acrolein was clearly very cytotoxic, it did not induce a significant mutagenic response in the presence or absence of metabolic activation.
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H E Caravello, and
J W Harbell
April 1988,
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R A Parent, and
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J W Harbell
December 2010,
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R A Parent, and
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J W Harbell
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R A Parent, and
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June 2005,
Toxicology in vitro : an international journal published in association with BIBRA,
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J W Harbell
March 2005,
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R A Parent, and
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J W Harbell
October 1981,
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R A Parent, and
H E Caravello, and
J W Harbell
January 1984,
Environmental mutagenesis,
R A Parent, and
H E Caravello, and
J W Harbell
June 1990,
Mutation research,
R A Parent, and
H E Caravello, and
J W Harbell
January 1983,
Environmental mutagenesis,
R A Parent, and
H E Caravello, and
J W Harbell
June 1981,
Mutation research,
