-transparent.png){kind=logo}
Vascular endothelial cells (EC) produced IL-1 alpha but not IL-1 beta into extracellular fluids. Vascular smooth muscle cells (SMC), on the other hand, produced both IL-1 alpha and IL-1 beta, and IL-1 beta produced was much higher than IL-1 alpha. The addition of recombinant human IL-1 beta or recombinant human TNF-alpha significantly enhanced IL-1 alpha production in EC, and IL-1 alpha and IL-1 beta production in SMC. IL-1 beta release was not observed even when EC were stimulated with TNF-alpha. These results suggest that the species of released form of IL-1 are different in different cell types and that cytokines enhance IL-1 alpha and IL-1 beta production in SMC and IL-1 alpha production in EC.
M Shingu, and
M Nobunaga, and
I Ezaki, and
K Yoshioka
December 1996,
The American journal of physiology,
M Shingu, and
M Nobunaga, and
I Ezaki, and
K Yoshioka
January 1991,
European cytokine network,
M Shingu, and
M Nobunaga, and
I Ezaki, and
K Yoshioka
July 1998,
Prostaglandins, leukotrienes, and essential fatty acids,
M Shingu, and
M Nobunaga, and
I Ezaki, and
K Yoshioka
February 2002,
Sheng li xue bao : [Acta physiologica Sinica],
M Shingu, and
M Nobunaga, and
I Ezaki, and
K Yoshioka
October 1997,
British journal of pharmacology,
M Shingu, and
M Nobunaga, and
I Ezaki, and
K Yoshioka
March 1991,
Immunology,
M Shingu, and
M Nobunaga, and
I Ezaki, and
K Yoshioka
January 2007,
Biochemical pharmacology,
M Shingu, and
M Nobunaga, and
I Ezaki, and
K Yoshioka
September 1993,
The American journal of pathology,
M Shingu, and
M Nobunaga, and
I Ezaki, and
K Yoshioka
November 1997,
Journal of immunology (Baltimore, Md. : 1950),
M Shingu, and
M Nobunaga, and
I Ezaki, and
K Yoshioka
February 1993,
Transplantation,
