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The effects of adoptive transfer of spleen cells from tumour-bearing mice on the growth of Moloney murine sarcoma virus (M-MuSV)-induced primary tumours in BALB/c mice were studied. The effects were in 2 directions, depending on the time of lymphocyte inoculation; when spleen cells from tumuor-bearing mice 12 days after M-MuSV inoculation were inoculated into recipient mice before M-MuSV inoculation, the appearance of tumours was significantly delayed and their incidence was reduced, whereas when these lymphocytes were inoculated after the development of tumours in recipient mice, tumour growth was significantly enhanced. The data indicated that these inhibiting and enhancing effects were mediated mainly by T cells. The mechanisms of the parodoxical effects were investigated.
H Kimura, and
T Aoki
April 1964,
Nature,
H Kimura, and
T Aoki
November 1975,
Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie,
H Kimura, and
T Aoki
January 1982,
Annales d'immunologie,
H Kimura, and
T Aoki
June 1978,
Acta pathologica et microbiologica Scandinavica. Section C, Immunology,
H Kimura, and
T Aoki
December 1979,
Journal of immunology (Baltimore, Md. : 1950),
H Kimura, and
T Aoki
January 1982,
Cancer immunology, immunotherapy : CII,
H Kimura, and
T Aoki
March 1986,
Nihon Geka Gakkai zasshi,
H Kimura, and
T Aoki
December 1971,
European journal of cancer,
H Kimura, and
T Aoki
March 1974,
Biomedicine / [publiee pour l'A.A.I.C.I.G.],
H Kimura, and
T Aoki
January 1999,
The Journal of international medical research,
