CCR6 as a possible therapeutic target in psoriasis. 2010

Michael N Hedrick, and Anke S Lonsdorf, and Sam T Hwang, and Joshua M Farber
National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Molecular Immunology, Inflammation Biology Section, Bethesda, MD 20892, USA.

BACKGROUND Psoriasis is a common, chronic autoimmune disease of the skin. Despite a number of effective treatments, new therapies are needed with enhanced efficacy, safety and convenience. Chemokine receptors are GPCRs that control leukocyte trafficking, and like other GPCRs, are good potential drug targets. The chemokine receptor CCR6 is expressed on the T(H)17 subset of CD4(+) T cells, which produces IL-17A/F, IL-22, TNF-alpha and other cytokines, and which has been implicated in the pathogenesis of psoriasis. CCR6 and its ligand, CCL20/MIP-3alpha, are highly expressed in psoriatic skin and CCR6 is necessary for the pathology induced in a mouse model of psoriasis-like inflammation. METHODS This review summarizes the evidence for the importance of the IL-23/T(H)17 axis, and in particular CCR6 and CCL20 in psoriasis, dating from 2000 to the present, and discusses the possibility of inhibiting CCR6 as a treatment for the disease. RESULTS The review informs the reader of the current thinking on the mechanisms of inflammation in psoriasis and the possible roles for CCR6 (and CCL20) in disease pathogenesis. CONCLUSIONS We conclude that CCR6 should be investigated as a potential therapeutic target in psoriasis.

UI MeSH Term Description Entries
D007249 Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. Innate Inflammatory Response,Inflammations,Inflammatory Response, Innate,Innate Inflammatory Responses
D011565 Psoriasis A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis. Palmoplantaris Pustulosis,Pustular Psoriasis of Palms and Soles,Pustulosis Palmaris et Plantaris,Pustulosis of Palms and Soles,Psoriases
D005786 Gene Expression Regulation Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation. Gene Action Regulation,Regulation of Gene Expression,Expression Regulation, Gene,Regulation, Gene Action,Regulation, Gene Expression
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D016503 Drug Delivery Systems Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity. Drug Targeting,Delivery System, Drug,Delivery Systems, Drug,Drug Delivery System,Drug Targetings,System, Drug Delivery,Systems, Drug Delivery,Targeting, Drug,Targetings, Drug
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D053759 Interleukin-23 A heterodimeric cytokine that plays a role in innate and adaptive immune responses. Interleukin-23 is comprised of a unique 19 kDa subunit and 40 kDa subunit that is shared with INTERLEUKIN-12. It is produced by DENDRITIC CELLS; MACROPHAGES and a variety of other immune cells IL-23,Interleukin 23
D054399 Receptors, CCR6 CCR receptors with specificity for CHEMOKINE CCL20. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; and DENDRITIC CELLS. Antigens, CD196,CC Chemokine Receptor 6,CCR6 Receptors,CD196 Antigens,CC Chemokine Receptors 6
D054418 Chemokine CCL20 A CC-type chemokine with specificity for CCR6 RECEPTORS. It has activity towards DENDRITIC CELLS; T-LYMPHOCYTES; and B-LYMPHOCYTES. CCL20 Chemokine,Exodus-1 Chemokine,MIP-3-alpha,Macrophage Inflammatory Protein 3 alpha,SCYA20 Chemokine,Small Inducible Cytokine A20,CCL20, Chemokine,Chemokine, CCL20,Chemokine, Exodus-1,Chemokine, SCYA20,Exodus 1 Chemokine

Related Publications

Michael N Hedrick, and Anke S Lonsdorf, and Sam T Hwang, and Joshua M Farber
July 2021, Autoimmunity reviews,
Michael N Hedrick, and Anke S Lonsdorf, and Sam T Hwang, and Joshua M Farber
July 2017, Medicina clinica,
Michael N Hedrick, and Anke S Lonsdorf, and Sam T Hwang, and Joshua M Farber
August 2011, The Journal of investigative dermatology,
Michael N Hedrick, and Anke S Lonsdorf, and Sam T Hwang, and Joshua M Farber
January 2014, Acta medica portuguesa,
Michael N Hedrick, and Anke S Lonsdorf, and Sam T Hwang, and Joshua M Farber
January 2023, Expert review of clinical pharmacology,
Michael N Hedrick, and Anke S Lonsdorf, and Sam T Hwang, and Joshua M Farber
July 2013, The Journal of investigative dermatology,
Michael N Hedrick, and Anke S Lonsdorf, and Sam T Hwang, and Joshua M Farber
April 2023, Antibodies (Basel, Switzerland),
Michael N Hedrick, and Anke S Lonsdorf, and Sam T Hwang, and Joshua M Farber
January 2011, Nature reviews. Rheumatology,
Michael N Hedrick, and Anke S Lonsdorf, and Sam T Hwang, and Joshua M Farber
December 2002, Expert opinion on therapeutic targets,
Michael N Hedrick, and Anke S Lonsdorf, and Sam T Hwang, and Joshua M Farber
November 2014, Acta oto-laryngologica,
Copied contents to your clipboard!