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Synthesis, selective anti-Helicobacter pylori activity, and cytotoxicity of novel N-substituted-2-oxo-2H-1-benzopyran-3-carboxamides. 2010
Franco Chimenti, and
Bruna Bizzarri, and
Adriana Bolasco, and
Daniela Secci, and
Paola Chimenti, and
Arianna Granese, and
Simone Carradori, and
Daniela Rivanera, and
Alessandra Zicari, and
M Maddalena Scaltrito, and
Francesca Sisto
Dipartimento di Chimica e Tecnologie del Farmaco, Università 'La Sapienza', P.le A. Moro 5, 00185 Rome, Italy.
N-substituted-3-carboxamido-coumarin derivatives were prepared and evaluated for selective antibacterial activity against 20 isolates of Helicobacter pylori clinical strains, including five metronidazole resistant ones. Some of them possessed the best activity against H. pylori metronidazole resistant strains with MIC values lower than the drug reference (metronidazole). Furthermore, anti-inflammatory activity through the inhibition of the IL-8 production was investigated.
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