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Concentration dependence of mutation in equigenerational exposures to methyl, ethyl, propyl, and butyl methanesulfonates has been determined in diploid human lymphoblasts and Salmonella typhimurium. Forward mutation was measured at the hypoxanthine guanine phosphoribosyltransferase locus in human lymphoblasts and at the putative guanine phosphoribosyltransferase locus in S. typhimurium. Reverse mutation at the his G46 locus was also measured in S. typhimurium. This analysis and previous reports support the conclusion that S. typhimurium and mammalian cells are essentially equisensitive to the mutagenic effects of ethyl methanesulfonate when concentration and exposure time are taken into account. Comparison of forward and reverse mutation assays in S. typhimurium reveals no important differences in sensitivities for the four compounds studied.
H Hoppe, and
T R Skopeck, and
H L Liber, and
W G Thilly
July 1982,
Cancer research,
H Hoppe, and
T R Skopeck, and
H L Liber, and
W G Thilly
February 1983,
Mutation research,
H Hoppe, and
T R Skopeck, and
H L Liber, and
W G Thilly
January 1977,
Journal of environmental pathology and toxicology,
H Hoppe, and
T R Skopeck, and
H L Liber, and
W G Thilly
February 1977,
Mutation research,
H Hoppe, and
T R Skopeck, and
H L Liber, and
W G Thilly
January 1981,
Analytical biochemistry,
H Hoppe, and
T R Skopeck, and
H L Liber, and
W G Thilly
June 1982,
Mutation research,
H Hoppe, and
T R Skopeck, and
H L Liber, and
W G Thilly
April 1978,
Mutation research,
H Hoppe, and
T R Skopeck, and
H L Liber, and
W G Thilly
October 1979,
Journal of the National Cancer Institute,
H Hoppe, and
T R Skopeck, and
H L Liber, and
W G Thilly
May 1986,
Mutation research,
H Hoppe, and
T R Skopeck, and
H L Liber, and
W G Thilly
July 1976,
Somatic cell genetics,
