Effects of paired-pulse transcranial magnetic stimulation of the motor cortex on perception of experimentally induced pain. 2010

Veit Mylius, and Anne Knaack, and Anja Haag, and Michael Teepker, and Wolfgang H Oertel, and Gregor Thut, and Hajo M Hamer, and Felix Rosenow
Department of Neurology, Philipps University Marburg, Marburg, Germany. mylius@med.uni-marburg.de

OBJECTIVE We investigated the influence of paired-pulse transcranial magnetic stimulation (ppTMS) of the motor cortex (M1) on perception of noxious electrical stimuli. The nociceptive flexion reflex response was assessed to determine spinal effects. METHODS In the first experiment, the effect of ppTMS of M1 on perception of noxious stimulation of the sural nerve was assessed by varying the stimulus onset asynchronies (SOAs) and the order of the stimulations (-400, -75, -25, 25, 125, 400 ms and control ppTMS, negative sign: ppTMS precedes the noxious stimulation). Effects of a preceding ppTMS on the RII and the RIII response of the nociceptive flexion reflex were investigated for SOAs of -400 and -75 ms. The effects of ppTMS of M1 and of the occipital cortex (Oz) on noxious stimulation of the radial nerve were investigated in a second experiment. Visual analogue scales were used to assess pain intensity and unpleasantness. RESULTS The results revealed increased pain unpleasantness scores for SOAs of -75, -25, 25, and 400 ms and decreased pain intensity scores for a SOA of -400 ms, when the sural nerve and M1 were stimulated. An increase of the area of the RII response was found for a SOA of -75 ms. For stimulation of the radial nerve, ppTMS of Oz but not of M1 increased the perceived pain at a SOA of 25 ms. CONCLUSIONS The facilitatory component of ppTMS led to increased pain perception when applied during the cortical process of Adelta fiber-mediated input, whereas the subsequent inhibitory component may lead to the opposite effect on the subsequent noxious stimulation.

UI MeSH Term Description Entries
D008297 Male Males
D009044 Motor Cortex Area of the FRONTAL LOBE concerned with primary motor control located in the dorsal PRECENTRAL GYRUS immediately anterior to the central sulcus. It is comprised of three areas: the primary motor cortex located on the anterior paracentral lobule on the medial surface of the brain; the premotor cortex located anterior to the primary motor cortex; and the supplementary motor area located on the midline surface of the hemisphere anterior to the primary motor cortex. Brodmann Area 4,Brodmann Area 6,Brodmann's Area 4,Brodmann's Area 6,Premotor Cortex and Supplementary Motor Cortex,Premotor and Supplementary Motor Cortices,Anterior Central Gyrus,Gyrus Precentralis,Motor Area,Motor Strip,Precentral Gyrus,Precentral Motor Area,Precentral Motor Cortex,Premotor Area,Premotor Cortex,Primary Motor Area,Primary Motor Cortex,Secondary Motor Areas,Secondary Motor Cortex,Somatic Motor Areas,Somatomotor Areas,Supplementary Motor Area,Area 4, Brodmann,Area 4, Brodmann's,Area 6, Brodmann,Area 6, Brodmann's,Area, Motor,Area, Precentral Motor,Area, Premotor,Area, Primary Motor,Area, Secondary Motor,Area, Somatic Motor,Area, Somatomotor,Area, Supplementary Motor,Brodmann's Area 6s,Brodmanns Area 4,Brodmanns Area 6,Central Gyrus, Anterior,Cortex, Motor,Cortex, Precentral Motor,Cortex, Premotor,Cortex, Primary Motor,Cortex, Secondary Motor,Cortices, Secondary Motor,Gyrus, Anterior Central,Gyrus, Precentral,Motor Area, Precentral,Motor Area, Primary,Motor Area, Secondary,Motor Area, Somatic,Motor Areas,Motor Cortex, Precentral,Motor Cortex, Primary,Motor Cortex, Secondary,Motor Strips,Precentral Motor Areas,Precentral Motor Cortices,Premotor Areas,Primary Motor Areas,Primary Motor Cortices,Secondary Motor Area,Secondary Motor Cortices,Somatic Motor Area,Somatomotor Area,Supplementary Motor Areas
D010146 Pain An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS. Suffering, Physical,Ache,Pain, Burning,Pain, Crushing,Pain, Migratory,Pain, Radiating,Pain, Splitting,Aches,Burning Pain,Burning Pains,Crushing Pain,Crushing Pains,Migratory Pain,Migratory Pains,Pains, Burning,Pains, Crushing,Pains, Migratory,Pains, Radiating,Pains, Splitting,Physical Suffering,Physical Sufferings,Radiating Pain,Radiating Pains,Splitting Pain,Splitting Pains,Sufferings, Physical
D010147 Pain Measurement Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies. Analgesia Tests,Analogue Pain Scale,Formalin Test,McGill Pain Questionnaire,Nociception Tests,Pain Assessment,Pain Intensity,Pain Severity,Tourniquet Pain Test,Visual Analogue Pain Scale,Analog Pain Scale,Assessment, Pain,McGill Pain Scale,Visual Analog Pain Scale,Analgesia Test,Analog Pain Scales,Analogue Pain Scales,Formalin Tests,Intensity, Pain,Measurement, Pain,Nociception Test,Pain Assessments,Pain Intensities,Pain Measurements,Pain Questionnaire, McGill,Pain Scale, Analog,Pain Scale, Analogue,Pain Scale, McGill,Pain Severities,Pain Test, Tourniquet,Questionnaire, McGill Pain,Scale, Analog Pain,Scale, Analogue Pain,Scale, McGill Pain,Severity, Pain,Test, Analgesia,Test, Formalin,Test, Nociception,Test, Tourniquet Pain,Tests, Nociception,Tourniquet Pain Tests
D004558 Electric Stimulation Use of electric potential or currents to elicit biological responses. Stimulation, Electric,Electrical Stimulation,Electric Stimulations,Electrical Stimulations,Stimulation, Electrical,Stimulations, Electric,Stimulations, Electrical
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000704 Analysis of Variance A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable. ANOVA,Analysis, Variance,Variance Analysis,Analyses, Variance,Variance Analyses
D013497 Sural Nerve A branch of the tibial nerve which supplies sensory innervation to parts of the lower leg and foot. Nerve, Sural,Nerves, Sural,Sural Nerves

Related Publications

Veit Mylius, and Anne Knaack, and Anja Haag, and Michael Teepker, and Wolfgang H Oertel, and Gregor Thut, and Hajo M Hamer, and Felix Rosenow
August 2001, Experimental brain research,
Veit Mylius, and Anne Knaack, and Anja Haag, and Michael Teepker, and Wolfgang H Oertel, and Gregor Thut, and Hajo M Hamer, and Felix Rosenow
June 2001, Journal of neurophysiology,
Veit Mylius, and Anne Knaack, and Anja Haag, and Michael Teepker, and Wolfgang H Oertel, and Gregor Thut, and Hajo M Hamer, and Felix Rosenow
August 2006, Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology,
Veit Mylius, and Anne Knaack, and Anja Haag, and Michael Teepker, and Wolfgang H Oertel, and Gregor Thut, and Hajo M Hamer, and Felix Rosenow
November 2018, Brain topography,
Veit Mylius, and Anne Knaack, and Anja Haag, and Michael Teepker, and Wolfgang H Oertel, and Gregor Thut, and Hajo M Hamer, and Felix Rosenow
June 2010, Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology,
Veit Mylius, and Anne Knaack, and Anja Haag, and Michael Teepker, and Wolfgang H Oertel, and Gregor Thut, and Hajo M Hamer, and Felix Rosenow
November 2008, Neuroscience,
Veit Mylius, and Anne Knaack, and Anja Haag, and Michael Teepker, and Wolfgang H Oertel, and Gregor Thut, and Hajo M Hamer, and Felix Rosenow
September 2023, The European journal of neuroscience,
Veit Mylius, and Anne Knaack, and Anja Haag, and Michael Teepker, and Wolfgang H Oertel, and Gregor Thut, and Hajo M Hamer, and Felix Rosenow
June 2012, The Chinese journal of physiology,
Veit Mylius, and Anne Knaack, and Anja Haag, and Michael Teepker, and Wolfgang H Oertel, and Gregor Thut, and Hajo M Hamer, and Felix Rosenow
March 2009, Experimental brain research,
Veit Mylius, and Anne Knaack, and Anja Haag, and Michael Teepker, and Wolfgang H Oertel, and Gregor Thut, and Hajo M Hamer, and Felix Rosenow
October 2010, Neuroscience letters,
Copied contents to your clipboard!