Biomaterial Database

Quality of life in patients who have remitted from their first episode of psychosis. 2010

S M Cotton, and J F M Gleeson, and M Alvarez-Jimenez, and P D McGorry

Orygen Youth Health Research Centre, Centre for Youth Mental Health, The University of Melbourne, Australia. smcotton@unimelb.edu.au

BACKGROUND Quality of life (QoL) in first-episode psychosis (FEP) is strongly related to levels of psychopathology and may vary as a function of illness phase. QoL remains poorly understood in FEP. OBJECTIVE Characterise the nature and predictors of QoL in patients who have remitted from their first-episode of psychosis. METHODS Demographic characteristics, diagnoses, and psychopathology were assessed in 81 FEP patients. The World Health Organization Quality of Life Scale-Bref (WHOQoL-Bref) was used to assess QoL in these patients. Carer-related variables (expressed emotion and burden of care) were ascertained from 63 relatives. RESULTS Poorer QoL was associated with personality disorder, depression, mild psychotic positive symptoms, and impaired functioning. Carer-related factors such as emotional overinvolvement and burden of care were also associated with a reduction in patients' QoL. CONCLUSIONS Depression, functioning and family variables impacted on QoL, and need to be considered in terms of ongoing patient management.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D011237	Predictive Value of Tests	In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.	Negative Predictive Value,Positive Predictive Value,Predictive Value Of Test,Predictive Values Of Tests,Negative Predictive Values,Positive Predictive Values,Predictive Value, Negative,Predictive Value, Positive
D011618	Psychotic Disorders	Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent hallucinations. (From DSM-IV, 1994)	Psychoses,Psychosis, Brief Reactive,Schizoaffective Disorder,Schizophreniform Disorders,Psychosis,Brief Reactive Psychoses,Brief Reactive Psychosis,Disorder, Psychotic,Disorder, Schizoaffective,Disorder, Schizophreniform,Disorders, Psychotic,Disorders, Schizoaffective,Disorders, Schizophreniform,Psychoses, Brief Reactive,Psychotic Disorder,Reactive Psychoses, Brief,Reactive Psychosis, Brief,Schizoaffective Disorders,Schizophreniform Disorder
D011788	Quality of Life	A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral, social environment as well as health and disease.	HRQOL,Health-Related Quality Of Life,Life Quality,Health Related Quality Of Life
D012044	Regression Analysis	Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.	Regression Diagnostics,Statistical Regression,Analysis, Regression,Analyses, Regression,Diagnostics, Regression,Regression Analyses,Regression, Statistical,Regressions, Statistical,Statistical Regressions
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D012919	Social Behavior	Any behavior caused by or affecting another individual or group usually of the same species.	Sociality,Behavior, Social,Behaviors, Social,Social Behaviors