BIOMAT Database Logo BIOMAT Database Logo

Stability studies and structural characterization of pramipexole. 2010

Marta Łaszcz, and Kinga Trzcińska, and Marek Kubiszewski, and Bozenna Kosmacińska, and Magdalena Glice
Pharmaceutical Research Institute, Rydygiera 8, Warsaw, Poland. m.laszcz@ifarm.waw.pl

Stability studies of pramipexole dihydrochloride performed under following conditions of temperature and relative humidity (RH): 25 degrees C 60% RH and 40 degrees C 75% RH revealed its tendency to the water sorption and the monohydrate formation. The structural changes occurring during storage were studied by infrared spectroscopy and X-ray powder diffraction methods. The thermogravimetry technique was used to control the water sorption by the substance. Pramipexole dihydrochloride monohydrate was characterized by nuclear magnetic resonance and X-ray single crystal diffraction methods. The monohydrate crystallizes in the orthorhombic crystal system in the space group P212121.

UI MeSH Term Description Entries
D004355 Drug Stability The chemical and physical integrity of a pharmaceutical product. Drug Shelf Life,Drugs Shelf Lives,Shelf Life, Drugs,Drug Stabilities,Drugs Shelf Life,Drugs Shelf Live,Life, Drugs Shelf,Shelf Life, Drug,Shelf Live, Drugs,Shelf Lives, Drugs
D006860 Hydrogen Bonding A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds. Hydrogen Bonds,Bond, Hydrogen,Hydrogen Bond
D000077487 Pramipexole A benzothiazole derivative and dopamine agonist with antioxidant properties that is used in the treatment of PARKINSON DISEASE and RESTLESS LEGS SYNDROME. 2-Amino-4,5,6,7-tetrahydro-6-propylaminobenzothiazole,2-Amino-6-propylaminotetrahydrobenzothiazole,4,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazole-diamine,6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine dihydrochloride monohydrate,Mirapex,Pramipexol,Pramipexol Dihydrobromide, (+-)-isomer,Pramipexol Dihydrochloride, (S)-isomer,Pramipexol, (+-)-isomer,Pramipexole Dihydrochloride,Pramipexole Dihydrochloride Anhydrous,Pramipexole Hydrochloride Monohydrate,SND-919,Sifrol,2 Amino 6 propylaminotetrahydrobenzothiazole,SND 919
D000978 Antiparkinson Agents Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists. Antiparkinson Drugs,Antiparkinsonian Agents,Antiparkinsonians,Agents, Antiparkinson,Agents, Antiparkinsonian,Drugs, Antiparkinson
D013818 Thermogravimetry Technique whereby the weight of a sample can be followed over a period of time while its temperature is being changed (usually increased at a constant rate). Thermogravimetries
D014961 X-Ray Diffraction The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Xray Diffraction,Diffraction, X-Ray,Diffraction, Xray,Diffractions, X-Ray,Diffractions, Xray,X Ray Diffraction,X-Ray Diffractions,Xray Diffractions
D052160 Benzothiazoles Compounds with a benzene ring fused to a thiazole ring.

Related Publications

Marta Łaszcz, and Kinga Trzcińska, and Marek Kubiszewski, and Bozenna Kosmacińska, and Magdalena Glice
Linolenic acid grafted hyaluronan: Process development, structural characterization, biological assessing, and stability studies.
November 2016, Carbohydrate polymers,
Marta Łaszcz, and Kinga Trzcińska, and Marek Kubiszewski, and Bozenna Kosmacińska, and Magdalena Glice
Structural characterization and stability analysis of phosphorylated nitrosohemoglobin.
March 2022, Food chemistry,
Marta Łaszcz, and Kinga Trzcińska, and Marek Kubiszewski, and Bozenna Kosmacińska, and Magdalena Glice
Structural characterization and thermal stability of Notothenia coriiceps metallothionein.
March 2001, The Biochemical journal,
Marta Łaszcz, and Kinga Trzcińska, and Marek Kubiszewski, and Bozenna Kosmacińska, and Magdalena Glice
Synthesis, structural characterization, computational studies and stability evaluations of metal ions and ZnONPs complexes with dimercaptosuccinic acid.
January 2021, Heliyon,
Marta Łaszcz, and Kinga Trzcińska, and Marek Kubiszewski, and Bozenna Kosmacińska, and Magdalena Glice
rAAV vector product characterization and stability studies.
January 2011, Methods in molecular biology (Clifton, N.J.),
Marta Łaszcz, and Kinga Trzcińska, and Marek Kubiszewski, and Bozenna Kosmacińska, and Magdalena Glice
Pre-clinical studies of pramipexole: clinical relevance.
May 2000, European journal of neurology,
Marta Łaszcz, and Kinga Trzcińska, and Marek Kubiszewski, and Bozenna Kosmacińska, and Magdalena Glice
Stability Studies and Characterization of Glutathione-Loaded Nanoemulsion.
January 2018, Journal of cosmetic science,
Marta Łaszcz, and Kinga Trzcińska, and Marek Kubiszewski, and Bozenna Kosmacińska, and Magdalena Glice
C4'-Fluorinated Oligodeoxynucleotides: Synthesis, Stability, Structural Studies.
October 2021, Chemistry (Weinheim an der Bergstrasse, Germany),
Marta Łaszcz, and Kinga Trzcińska, and Marek Kubiszewski, and Bozenna Kosmacińska, and Magdalena Glice
Tris(hydroxymethyl) aminomethane salt of ramipril: synthesis, structural characterization from X-ray powder diffraction and stability studies.
November 2012, Journal of pharmaceutical and biomedical analysis,
Marta Łaszcz, and Kinga Trzcińska, and Marek Kubiszewski, and Bozenna Kosmacińska, and Magdalena Glice
Studies on the structural stability of haemoglobin E.
July 1975, Journal of the Medical Association of Thailand = Chotmaihet thangphaet,
Copied contents to your clipboard!