BIOMAT Database Logo BIOMAT Database Logo

Tissue distribution of (35)S-labelled perfluorooctane sulfonate (PFOS) in C57Bl/6 mice following late gestational exposure. 2010

D Borg, and J Bogdanska, and M Sundström, and S Nobel, and H Håkansson, and Å Bergman, and J W DePierre, and K Halldin, and U Bergström
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. daniel.borg@ki.se

Exposure of rodents in utero to perfluorooctane sulfonate (PFOS) impairs perinatal development and survival. Following intravenous or gavage exposure of C57Bl/6 mouse dams on gestational day (GD) 16 to (35)S-PFOS (12.5mg/kg), we determined the distribution in dams, fetuses (GD18 and GD20) and pups (postnatal day 1, PND1) employing whole-body autoradiography and liquid scintillation counting. In dams, levels were highest in liver and lungs. After placental transfer, (35)S-PFOS was present on GD18 at 2-3 times higher levels in lungs, liver and kidneys than in maternal blood. In PND1 pups, levels in lungs were significantly higher than in GD18 fetuses. A heterogeneous distribution of (35)S-PFOS was observed in brains of fetuses and pups, with levels higher than in maternal brain. This first demonstration of substantial localization of PFOS to both perinatal and adult lungs is consistent with evidence describing the lung as a target for the toxicity of PFOS at these ages.

UI MeSH Term Description Entries
D007668 Kidney Body organ that filters blood for the secretion of URINE and that regulates ion concentrations. Kidneys
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008168 Lung Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood. Lungs
D008431 Maternal-Fetal Exchange Exchange of substances between the maternal blood and the fetal blood at the PLACENTA via PLACENTAL CIRCULATION. The placental barrier excludes microbial or viral transmission. Transplacental Exposure,Exchange, Maternal-Fetal,Exposure, Transplacental,Maternal Fetal Exchange
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D004785 Environmental Pollutants Substances or energies, for example heat or light, which when introduced into the air, water, or land threaten life or health of individuals or ECOSYSTEMS. Environmental Pollutant,Pollutant,Pollutants,Pollutants, Environmental,Pollutant, Environmental
D005260 Female Females
D005312 Fetal Blood Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery. Cord Blood,Umbilical Cord Blood,Blood, Cord,Blood, Fetal,Blood, Umbilical Cord,Bloods, Cord,Bloods, Fetal,Bloods, Umbilical Cord,Cord Blood, Umbilical,Cord Bloods,Cord Bloods, Umbilical,Fetal Bloods,Umbilical Cord Bloods

Related Publications

D Borg, and J Bogdanska, and M Sundström, and S Nobel, and H Håkansson, and Å Bergman, and J W DePierre, and K Halldin, and U Bergström
Induction of p53-mediated apoptosis in splenocytes and thymocytes of C57BL/6 mice exposed to perfluorooctane sulfonate (PFOS).
October 2012, Toxicology and applied pharmacology,
D Borg, and J Bogdanska, and M Sundström, and S Nobel, and H Håkansson, and Å Bergman, and J W DePierre, and K Halldin, and U Bergström
PFOS or PreFOS? Are perfluorooctane sulfonate precursors (PreFOS) important determinants of human and environmental perfluorooctane sulfonate (PFOS) exposure?
November 2010, Journal of environmental monitoring : JEM,
D Borg, and J Bogdanska, and M Sundström, and S Nobel, and H Håkansson, and Å Bergman, and J W DePierre, and K Halldin, and U Bergström
Neurotoxicity of perfluorooctane sulfonate (PFOS) in rats and mice after single oral exposure.
October 2009, The Journal of toxicological sciences,
D Borg, and J Bogdanska, and M Sundström, and S Nobel, and H Håkansson, and Å Bergman, and J W DePierre, and K Halldin, and U Bergström
Multilayered glycoproteomic analysis reveals the hepatotoxic mechanism in perfluorooctane sulfonate (PFOS) exposure mice.
January 2021, Environmental pollution (Barking, Essex : 1987),
D Borg, and J Bogdanska, and M Sundström, and S Nobel, and H Håkansson, and Å Bergman, and J W DePierre, and K Halldin, and U Bergström
Effects of perfluorooctane sulfonate (PFOS) exposure on markers of inflammation in female B6C3F1 mice.
January 2011, Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering,
D Borg, and J Bogdanska, and M Sundström, and S Nobel, and H Håkansson, and Å Bergman, and J W DePierre, and K Halldin, and U Bergström
Chronic perfluorooctane sulfonate (PFOS) exposure induces hepatic steatosis in zebrafish.
July 2016, Aquatic toxicology (Amsterdam, Netherlands),
D Borg, and J Bogdanska, and M Sundström, and S Nobel, and H Håkansson, and Å Bergman, and J W DePierre, and K Halldin, and U Bergström
Developmental toxicity in white leghorn chickens following in ovo exposure to perfluorooctane sulfonate (PFOS).
June 2009, Reproductive toxicology (Elmsford, N.Y.),
D Borg, and J Bogdanska, and M Sundström, and S Nobel, and H Håkansson, and Å Bergman, and J W DePierre, and K Halldin, and U Bergström
Gestational exposure to perfluorooctane sulfonate suppresses immune function in B6C3F1 mice.
May 2008, Toxicological sciences : an official journal of the Society of Toxicology,
D Borg, and J Bogdanska, and M Sundström, and S Nobel, and H Håkansson, and Å Bergman, and J W DePierre, and K Halldin, and U Bergström
Behavioral effects in adult mice exposed to perfluorooctane sulfonate (PFOS).
December 2007, Toxicology,
D Borg, and J Bogdanska, and M Sundström, and S Nobel, and H Håkansson, and Å Bergman, and J W DePierre, and K Halldin, and U Bergström
Sediment-water distribution of perfluorooctane sulfonate (PFOS) in Yangtze River Estuary.
May 2010, Environmental pollution (Barking, Essex : 1987),
Copied contents to your clipboard!