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Bisbenzamidines as antifungal agents. are both amidine functions required to observe an anti-Pneumocystis carinii activity? 2010
Julien Laurent, and
Dimitri Stanicki, and
Tien L Huang, and
Eduardo Dei-Cas, and
Muriel Pottier, and
El Mouktar Aliouat, and
Jean Jacques Vanden Eynde
Laboratory of Organic Chemistry, Faculty of Sciences, University of Mons-UMONS, 20 place du parc, B-7000 Mons, Belgium.
A library of 19 novel 4-(4-phenylpiperazine-1-yl)benzamidines has been synthesized and evaluated in vitro against Pneumocystis carinii. Among these compounds, N-ethyl- and N-hexyl-4-(4-phenylpiperazine-1-yl)benzamidines emerged as the most promising compounds, with inhibition percentages at 10.0 microg/mL of 87% and 96%, respectively. Those compounds remained active at 0.1 microg/mL.
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