Biomaterial Database

Plaque-growth inhibiting effect of chewing gum containing urea hydrogen peroxide. 1991

H Etemadzadeh

Department of Periodontology, University of Helsinki, Finland.

The plaque-reducing effect of a chewing gum containing hydrogen peroxide was assessed. 12 dental hygienist students participated in a double-blind 3 x randomly crossed-over study. During the 4-day test periods, from Monday to Friday, no oral hygiene measures were allowed other than chewing 2 pieces of gum for approximately 10 min 5 x daily. The 800 mg pieces of gum were V6+regular (V6+) containing 0.4 g sorbitol and 6.3 mg hydrogen peroxide, V6 placebo gum (PLAC) containing 0.45 g sorbitol and no hydrogen peroxide, and only the gum base (GB) as a negative control. The quantity of plaque was assessed using the plaque index and the visible plaque index, and by scraping "all" plaque off the teeth in half the mouth during 2.5 min for determination of plaque wet weight. With all 3 measurements, chewing of the hydrogen peroxide-releasing gum (V6+) resulted in significantly lower plaque increments, from Monday to Friday, than chewing of the gum base (P less than 0.05). Chewing of the V6 placebo gum (PLAC) resulted in plaque scores which differed from neither those recorded after use of the hydrogen peroxide releasing (V6+) nor the placebo (GB) gums. The observed plaque-growth inhibiting effect of the hydrogen peroxide-releasing chewing gum in the present study was found to be of limited clinical significance.

UI	MeSH Term	Description	Entries
D011897	Random Allocation	A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.	Randomization,Allocation, Random
D002638	Chewing Gum	A preparation of chicle, sometimes mixed with other plastic substances, sweetened and flavored. It is masticated usually for pleasure as a candy substitute but it sometimes acts as a vehicle for the administration of medication.	Chewing Gums,Gum, Chewing,Gums, Chewing
D003773	Dental Plaque	A film that attaches to teeth, often causing DENTAL CARIES and GINGIVITIS. It is composed of MUCINS, secreted from salivary glands, and microorganisms.	Plaque, Dental
D003774	Dental Plaque Index	An index which scores the degree of dental plaque accumulation.	Dental Plaque Indexes,Dental Plaque Indices,Index, Dental Plaque,Indexes, Dental Plaque,Indices, Dental Plaque
D004311	Double-Blind Method	A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.	Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked
D005069	Evaluation Studies as Topic	Works about studies that determine the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies.	Critique,Evaluation Indexes,Evaluation Methodology,Evaluation Report,Evaluation Research,Methodology, Evaluation,Pre-Post Tests,Qualitative Evaluation,Quantitative Evaluation,Theoretical Effectiveness,Use-Effectiveness,Critiques,Effectiveness, Theoretical,Evaluation Methodologies,Evaluation Reports,Evaluation, Qualitative,Evaluation, Quantitative,Evaluations, Qualitative,Evaluations, Quantitative,Indexes, Evaluation,Methodologies, Evaluation,Pre Post Tests,Pre-Post Test,Qualitative Evaluations,Quantitative Evaluations,Report, Evaluation,Reports, Evaluation,Research, Evaluation,Test, Pre-Post,Tests, Pre-Post,Use Effectiveness
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006861	Hydrogen Peroxide	A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.	Hydrogen Peroxide (H2O2),Hydroperoxide,Oxydol,Perhydrol,Superoxol,Peroxide, Hydrogen
D013012	Sorbitol	A polyhydric alcohol with about half the sweetness of sucrose. Sorbitol occurs naturally and is also produced synthetically from glucose. It was formerly used as a diuretic and may still be used as a laxative and in irrigating solutions for some surgical procedures. It is also used in many manufacturing processes, as a pharmaceutical aid, and in several research applications.	Glucitol,Medevac,Sorbilax,Yal,klysma Sorbit