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A large European multicentric cohort study has been coordinated by the International Agency for Research on Cancer with the objectives of investigating the dose-response relationship between liver cancer and exposure to vinyl chloride and assessing cancer risk for sites other than the liver. A nearly threefold increase in liver cancer was detected on the basis of 24 observed deaths and 8.4 expected (standardized mortality ratio 286, 95% confidence interval 186-425). The excess from liver cancer was clearly related to time since first exposure, duration of employment, and estimated ranked and quantitative exposures. Other cancer sites investigated on the basis of a priori hypotheses were either not in excess (lung) or apparently unrelated to the exposure variables (brain and lymphoma).
L Simonato, and
K A L'Abbé, and
A Andersen, and
S Belli, and
P Comba, and
G Engholm, and
G Ferro, and
L Hagmar, and
S Langård, and
I Lundberg
February 1984,
British journal of industrial medicine,
L Simonato, and
K A L'Abbé, and
A Andersen, and
S Belli, and
P Comba, and
G Engholm, and
G Ferro, and
L Hagmar, and
S Langård, and
I Lundberg
August 1974,
Lancet (London, England),
L Simonato, and
K A L'Abbé, and
A Andersen, and
S Belli, and
P Comba, and
G Engholm, and
G Ferro, and
L Hagmar, and
S Langård, and
I Lundberg
June 1975,
Environmental health perspectives,
L Simonato, and
K A L'Abbé, and
A Andersen, and
S Belli, and
P Comba, and
G Engholm, and
G Ferro, and
L Hagmar, and
S Langård, and
I Lundberg
September 1974,
Lancet (London, England),
L Simonato, and
K A L'Abbé, and
A Andersen, and
S Belli, and
P Comba, and
G Engholm, and
G Ferro, and
L Hagmar, and
S Langård, and
I Lundberg
October 1974,
Lancet (London, England),
L Simonato, and
K A L'Abbé, and
A Andersen, and
S Belli, and
P Comba, and
G Engholm, and
G Ferro, and
L Hagmar, and
S Langård, and
I Lundberg
September 1974,
Lancet (London, England),
L Simonato, and
K A L'Abbé, and
A Andersen, and
S Belli, and
P Comba, and
G Engholm, and
G Ferro, and
L Hagmar, and
S Langård, and
I Lundberg
January 2000,
Occupational and environmental medicine,
L Simonato, and
K A L'Abbé, and
A Andersen, and
S Belli, and
P Comba, and
G Engholm, and
G Ferro, and
L Hagmar, and
S Langård, and
I Lundberg
March 1983,
Journal of UOEH,
L Simonato, and
K A L'Abbé, and
A Andersen, and
S Belli, and
P Comba, and
G Engholm, and
G Ferro, and
L Hagmar, and
S Langård, and
I Lundberg
November 2001,
Epidemiology (Cambridge, Mass.),
L Simonato, and
K A L'Abbé, and
A Andersen, and
S Belli, and
P Comba, and
G Engholm, and
G Ferro, and
L Hagmar, and
S Langård, and
I Lundberg
April 1987,
British journal of industrial medicine,
