Epithelialization and blood flow in painlessly inflicted small suction blister wounds were studied in healthy volunteers (n = 26) using evaporimetry and laser Doppler flowmetry (LDF), respectively. As expected, the evaporation rate normalized faster in wounds covered by an occlusive film than in wounds covered with gauze. The evaporimetry technique was found to be a simple alternative to the biopsy-based methods that have previously been used in humans. Blood flow was increased after 25 min of suctioning, and the hyperemia increased further after equalization to atmospheric pressure. This wound hyperemia (day 1) was more pronounced than that observed during heating of adjacent skin, and more pronounced at a pressure of 400 mm Hg below atmospheric pressure than at 200 mm Hg below. The hyperemic response lasted for some days and was similar on arm and foot. A mechanical LDF linear scanner was used to create a flow profile across the wound into the adjacent skin. Six months after inflicting the lesions there was no visible scar. The findings suggest that this blister wound model may be useful for studying epithelialization and microcirculatory events after trauma and during early wound healing in humans.