BIOMAT Database Logo BIOMAT Database Logo

Consumption of sericin reduces serum lipids, ameliorates glucose tolerance and elevates serum adiponectin in rats fed a high-fat diet. 2010

Yukako Okazaki, and Shoko Kakehi, and Yonghui Xu, and Kazuhisa Tsujimoto, and Masahiro Sasaki, and Hiroshi Ogawa, and Norihisa Kato
Faculty of Human Life Sciences, Fuji Women's University, Ishikari, Japan. yokazaki@fujijoshi.ac.jp

The effect was examined of dietary sericin on the lipid and carbohydrate metabolism in rats fed with a high-fat diet. The rats were fed with a 20% beef tallow diet with or without sericin at the level of 4% for 5 weeks. The final body weight and white adipose tissue weight were unaffected by dietary manipulation. The consumption of sericin significantly reduced the serum levels of triglyceride, cholesterol, phospholipids and free fatty acids. Serum very-low-density lipoprotein (VLDL)-triglyceride, VLDL-cholesterol, low-density lipoprotein (LDL)-cholesterol and LDL-phospholipids were also significantly reduced by the sericin intake. Liver triglyceride and the activities of glucose 6-phosphate dehydrogenase and malic enzyme, the lipogenic enzymes, were also reduced by the sericin intake. Dietary sericin caused a marked elevation in serum adiponectin. The consumption of sericin suppressed the increases in plasma glucose and insulin levels after an intraperitoneal glucose injection. These results imply the usefulness of sericin for improving the lipid and carbohydrate metabolism in rats fed on a high-fat diet.

UI MeSH Term Description Entries
D008055 Lipids A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed) Lipid
D008297 Male Males
D004041 Dietary Fats Fats present in food, especially in animal products such as meat, meat products, butter, ghee. They are present in lower amounts in nuts, seeds, and avocados. Fats, Dietary,Dietary Fat,Fat, Dietary
D004044 Dietary Proteins Proteins obtained from foods. They are the main source of the ESSENTIAL AMINO ACIDS. Proteins, Dietary,Dietary Protein,Protein, Dietary
D004435 Eating The consumption of edible substances. Dietary Intake,Feed Intake,Food Intake,Macronutrient Intake,Micronutrient Intake,Nutrient Intake,Nutritional Intake,Ingestion,Dietary Intakes,Feed Intakes,Intake, Dietary,Intake, Feed,Intake, Food,Intake, Macronutrient,Intake, Micronutrient,Intake, Nutrient,Intake, Nutritional,Macronutrient Intakes,Micronutrient Intakes,Nutrient Intakes,Nutritional Intakes
D005947 Glucose A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement. Dextrose,Anhydrous Dextrose,D-Glucose,Glucose Monohydrate,Glucose, (DL)-Isomer,Glucose, (alpha-D)-Isomer,Glucose, (beta-D)-Isomer,D Glucose,Dextrose, Anhydrous,Monohydrate, Glucose
D000284 Administration, Oral The giving of drugs, chemicals, or other substances by mouth. Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D017207 Rats, Sprague-Dawley A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company. Holtzman Rat,Rats, Holtzman,Sprague-Dawley Rat,Rats, Sprague Dawley,Holtzman Rats,Rat, Holtzman,Rat, Sprague-Dawley,Sprague Dawley Rat,Sprague Dawley Rats,Sprague-Dawley Rats
D047030 Sericins A serine-rich sticky protein secreted by MOTHS. Generally, the term refers to silkworm silk gum protein secreted in the middle section of silk gland cells of SILKWORMS, Bombyx mori. Sericin acts as a cement and coating for the two fibroin filaments in a silk strand and is readily soluble in mild alkaline solution. Sericin,Sericin-1,Silk Gum Proteins,Proteins, Silk Gum,Sericin 1

Related Publications

Yukako Okazaki, and Shoko Kakehi, and Yonghui Xu, and Kazuhisa Tsujimoto, and Masahiro Sasaki, and Hiroshi Ogawa, and Norihisa Kato
Consumption of a resistant protein, sericin, elevates fecal immunoglobulin A, mucins, and cecal organic acids in rats fed a high-fat diet.
November 2011, The Journal of nutrition,
Yukako Okazaki, and Shoko Kakehi, and Yonghui Xu, and Kazuhisa Tsujimoto, and Masahiro Sasaki, and Hiroshi Ogawa, and Norihisa Kato
Bitter melon (Momordica charantia) reduces adiposity, lowers serum insulin and normalizes glucose tolerance in rats fed a high fat diet.
April 2003, The Journal of nutrition,
Yukako Okazaki, and Shoko Kakehi, and Yonghui Xu, and Kazuhisa Tsujimoto, and Masahiro Sasaki, and Hiroshi Ogawa, and Norihisa Kato
TRAIL reduces impaired glucose tolerance and NAFLD in the high-fat diet fed mouse.
January 2018, Clinical science (London, England : 1979),
Yukako Okazaki, and Shoko Kakehi, and Yonghui Xu, and Kazuhisa Tsujimoto, and Masahiro Sasaki, and Hiroshi Ogawa, and Norihisa Kato
Green tea decoction improves glucose tolerance and reduces weight gain of rats fed normal and high-fat diet.
May 2014, The Journal of nutritional biochemistry,
Yukako Okazaki, and Shoko Kakehi, and Yonghui Xu, and Kazuhisa Tsujimoto, and Masahiro Sasaki, and Hiroshi Ogawa, and Norihisa Kato
Oxyntomodulin ameliorates glucose intolerance in mice fed a high-fat diet.
January 2008, American journal of physiology. Endocrinology and metabolism,
Yukako Okazaki, and Shoko Kakehi, and Yonghui Xu, and Kazuhisa Tsujimoto, and Masahiro Sasaki, and Hiroshi Ogawa, and Norihisa Kato
Chronic glucokinase activation reduces glycaemia and improves glucose tolerance in high-fat diet fed mice.
August 2011, European journal of pharmacology,
Yukako Okazaki, and Shoko Kakehi, and Yonghui Xu, and Kazuhisa Tsujimoto, and Masahiro Sasaki, and Hiroshi Ogawa, and Norihisa Kato
Palmatine ameliorates high fat diet induced impaired glucose tolerance.
September 2020, Biological research,
Yukako Okazaki, and Shoko Kakehi, and Yonghui Xu, and Kazuhisa Tsujimoto, and Masahiro Sasaki, and Hiroshi Ogawa, and Norihisa Kato
Spent turmeric reduces fat mass in rats fed a high-fat diet.
April 2016, Food & function,
Yukako Okazaki, and Shoko Kakehi, and Yonghui Xu, and Kazuhisa Tsujimoto, and Masahiro Sasaki, and Hiroshi Ogawa, and Norihisa Kato
Consumption of curcumin elevates fecal immunoglobulin A, an index of intestinal immune function, in rats fed a high-fat diet.
January 2010, Journal of nutritional science and vitaminology,
Yukako Okazaki, and Shoko Kakehi, and Yonghui Xu, and Kazuhisa Tsujimoto, and Masahiro Sasaki, and Hiroshi Ogawa, and Norihisa Kato
Glucose tolerance, lipids, and GLP-1 secretion in JCR:LA-cp rats fed a high protein fiber diet.
January 2008, Obesity (Silver Spring, Md.),
Copied contents to your clipboard!