-transparent.png){kind=logo}
1. Effects of 8-(N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate hydrochloride (TMB-8), an inhibitor of intracellular calcium release, on renal function were examined in anaesthetized dogs. 2. Intrarenal arterial infusion of TMB-8 (0.03 and 0.1 mg/kg per min) increased urine flow rate, urinary sodium excretion and fractional excretion of sodium without affecting blood pressure, renal blood flow or glomerular filtration rate. 3. The results suggest that TMB-8 inhibits tubular sodium reabsorption to induce natriuresis.
Related Publications
A Takahara, and
A Ogasawara, and
M Suzuki-Kusaba, and
H Hisa, and
S Satoh
November 1991,
The Journal of physiology,
A Takahara, and
A Ogasawara, and
M Suzuki-Kusaba, and
H Hisa, and
S Satoh
May 1998,
Clinical and experimental pharmacology & physiology,
A Takahara, and
A Ogasawara, and
M Suzuki-Kusaba, and
H Hisa, and
S Satoh
August 1996,
British journal of pharmacology,
A Takahara, and
A Ogasawara, and
M Suzuki-Kusaba, and
H Hisa, and
S Satoh
January 1994,
Archives internationales de pharmacodynamie et de therapie,
A Takahara, and
A Ogasawara, and
M Suzuki-Kusaba, and
H Hisa, and
S Satoh
January 1995,
Archives internationales de pharmacodynamie et de therapie,
A Takahara, and
A Ogasawara, and
M Suzuki-Kusaba, and
H Hisa, and
S Satoh
March 1991,
Journal of ethnopharmacology,
A Takahara, and
A Ogasawara, and
M Suzuki-Kusaba, and
H Hisa, and
S Satoh
January 1983,
Nephrologie,
A Takahara, and
A Ogasawara, and
M Suzuki-Kusaba, and
H Hisa, and
S Satoh
October 2000,
Cardiovascular drugs and therapy,
A Takahara, and
A Ogasawara, and
M Suzuki-Kusaba, and
H Hisa, and
S Satoh
October 1993,
European journal of pharmacology,
A Takahara, and
A Ogasawara, and
M Suzuki-Kusaba, and
H Hisa, and
S Satoh
January 1985,
The Journal of membrane biology,
