-transparent.png){kind=logo}
A monoclonal antibody which reacts preferentially with human bone alkaline phosphatase (AP) has been developed using human osteosarcoma bone AP as an immunogen. The antibody with the highest selectivity shows about three- and a-half fold greater binding to bone than to liver AP. The selectivity was confirmed using mixtures of authentic samples of the bone and liver isoenzymes. Its selectivity was also shown by measurements of bone AP in sera from patients with either bone or liver diseases. Such a selective antibody could lead to the development of a monoclonal antibody highly specific for bone AP which can be used for a more sensitive approach for quantitative analysis of the isoenzyme.
K Masuhara, and
R Yoshikawa, and
K Takaoka, and
K Ono, and
D C Morris, and
H C Anderson
January 2005,
Human antibodies,
K Masuhara, and
R Yoshikawa, and
K Takaoka, and
K Ono, and
D C Morris, and
H C Anderson
December 1983,
Nihon Sanka Fujinka Gakkai zasshi,
K Masuhara, and
R Yoshikawa, and
K Takaoka, and
K Ono, and
D C Morris, and
H C Anderson
January 2009,
Pathology international,
K Masuhara, and
R Yoshikawa, and
K Takaoka, and
K Ono, and
D C Morris, and
H C Anderson
December 1982,
Clinica chimica acta; international journal of clinical chemistry,
K Masuhara, and
R Yoshikawa, and
K Takaoka, and
K Ono, and
D C Morris, and
H C Anderson
November 1995,
Clinical chemistry,
K Masuhara, and
R Yoshikawa, and
K Takaoka, and
K Ono, and
D C Morris, and
H C Anderson
January 1990,
Bone,
K Masuhara, and
R Yoshikawa, and
K Takaoka, and
K Ono, and
D C Morris, and
H C Anderson
February 1986,
Japanese journal of cancer research : Gann,
K Masuhara, and
R Yoshikawa, and
K Takaoka, and
K Ono, and
D C Morris, and
H C Anderson
January 1990,
Clinica chimica acta; international journal of clinical chemistry,
K Masuhara, and
R Yoshikawa, and
K Takaoka, and
K Ono, and
D C Morris, and
H C Anderson
April 1990,
Molecular and biochemical parasitology,
K Masuhara, and
R Yoshikawa, and
K Takaoka, and
K Ono, and
D C Morris, and
H C Anderson
March 1981,
Tissue antigens,
