X-ray-induced radioresistance against high-LET radiations from accelerated heavy ions in mice. 2010

Bing Wang, and Kaoru Tanaka, and Guillaume Varès, and Yi Shang, and Kazuko Fujita, and Yasuharu Ninomiya, and Tetsuo Nakajima, and Kiyomi Eguchi-Kasai, and Mitsuru Nenoi
Research Center for Radiation Protection, National Institute of Radiological Sciences, Anagawa 4-9-1, Inage-ku, Chiba 263-8555, Japan. jp2813km@nirs.go.jp

Induction of an adaptive response by priming X rays in combination with challenge irradiations from high-LET accelerated heavy ions was attempted in young adult female C57BL/6J Jms mice using 30-day survival after the challenge irradiations as an index. Three kinds of accelerated heavy ions from monoenergetic beams of carbon, silicon and iron ions with LETs of about 15, 55 and 200 keV/μm, respectively, were examined. A priming low dose of 0.50 Gy X rays in combination with a challenging dose of 7.50 Gy was used in the animals serving as a positive control group to confirm the successful induction of an adaptive response. The priming low dose of 0.50 Gy X rays was also used in combination with accelerated heavy ions. The priming low dose of X rays significantly reduced the mortality from the high challenge doses of carbon or silicon particles but not from iron particles. These results indicate that an adaptive response could be induced by priming low-LET X rays in combination with subsequent challenge high-LET irradiations from certain kinds of accelerated heavy ions, and successful induction of an adaptive response would possibly be an event related to the LET and/or the type of heavy ions. This is the first time that the existence of an adaptive response induced by low-LET X rays against high-LET whole-body irradiation in mice has been demonstrated. These findings would provide new insight into the radiation-induced adaptive response in vivo.

UI MeSH Term Description Entries
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D011836 Radiation Tolerance The ability of some cells or tissues to survive lethal doses of IONIZING RADIATION. Tolerance depends on the species, cell type, and physical and chemical variables, including RADIATION-PROTECTIVE AGENTS and RADIATION-SENSITIZING AGENTS. Radiation Sensitivity,Radiosensitivity,Sensitivity, Radiation,Tolerance, Radiation,Radiation Sensitivities,Radiation Tolerances,Radiosensitivities,Sensitivities, Radiation,Tolerances, Radiation
D004307 Dose-Response Relationship, Radiation The relationship between the dose of administered radiation and the response of the organism or tissue to the radiation. Dose Response Relationship, Radiation,Dose-Response Relationships, Radiation,Radiation Dose-Response Relationship,Radiation Dose-Response Relationships,Relationship, Radiation Dose-Response,Relationships, Radiation Dose-Response
D005260 Female Females
D000222 Adaptation, Physiological The non-genetic biological changes of an organism in response to challenges in its ENVIRONMENT. Adaptation, Physiologic,Adaptations, Physiologic,Adaptations, Physiological,Adaptive Plasticity,Phenotypic Plasticity,Physiological Adaptation,Physiologic Adaptation,Physiologic Adaptations,Physiological Adaptations,Plasticity, Adaptive,Plasticity, Phenotypic
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014916 Whole-Body Irradiation Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms. Radiation, Whole-Body,Total Body Irradiation,Irradiation, Total Body,Irradiation, Whole-Body,Whole-Body Radiation,Irradiation, Whole Body,Irradiations, Total Body,Irradiations, Whole-Body,Radiation, Whole Body,Radiations, Whole-Body,Total Body Irradiations,Whole Body Irradiation,Whole Body Radiation,Whole-Body Irradiations,Whole-Body Radiations
D014965 X-Rays Penetrating electromagnetic radiation emitted when the inner orbital electrons of an atom are excited and release radiant energy. X-ray wavelengths range from 1 pm to 10 nm. Hard X-rays are the higher energy, shorter wavelength X-rays. Soft x-rays or Grenz rays are less energetic and longer in wavelength. The short wavelength end of the X-ray spectrum overlaps the GAMMA RAYS wavelength range. The distinction between gamma rays and X-rays is based on their radiation source. Grenz Ray,Grenz Rays,Roentgen Ray,Roentgen Rays,X Ray,X-Ray,Xray,Radiation, X,X-Radiation,Xrays,Ray, Grenz,Ray, Roentgen,Ray, X,Rays, Grenz,Rays, Roentgen,Rays, X,X Radiation,X Rays,X-Radiations
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D018499 Linear Energy Transfer Rate of energy dissipation along the path of charged particles. In radiobiology and health physics, exposure is measured in kiloelectron volts per micrometer of tissue (keV/micrometer T). Energy Transfer, Linear,LET,Transfer, Linear Energy

Related Publications

Bing Wang, and Kaoru Tanaka, and Guillaume Varès, and Yi Shang, and Kazuko Fujita, and Yasuharu Ninomiya, and Tetsuo Nakajima, and Kiyomi Eguchi-Kasai, and Mitsuru Nenoi
May 1980, Radiation research,
Bing Wang, and Kaoru Tanaka, and Guillaume Varès, and Yi Shang, and Kazuko Fujita, and Yasuharu Ninomiya, and Tetsuo Nakajima, and Kiyomi Eguchi-Kasai, and Mitsuru Nenoi
January 2016, Frontiers in oncology,
Bing Wang, and Kaoru Tanaka, and Guillaume Varès, and Yi Shang, and Kazuko Fujita, and Yasuharu Ninomiya, and Tetsuo Nakajima, and Kiyomi Eguchi-Kasai, and Mitsuru Nenoi
January 1967, Radiation research. Supplement,
Bing Wang, and Kaoru Tanaka, and Guillaume Varès, and Yi Shang, and Kazuko Fujita, and Yasuharu Ninomiya, and Tetsuo Nakajima, and Kiyomi Eguchi-Kasai, and Mitsuru Nenoi
December 2004, Uchu Seibutsu Kagaku,
Bing Wang, and Kaoru Tanaka, and Guillaume Varès, and Yi Shang, and Kazuko Fujita, and Yasuharu Ninomiya, and Tetsuo Nakajima, and Kiyomi Eguchi-Kasai, and Mitsuru Nenoi
June 1998, Journal of radiation research,
Bing Wang, and Kaoru Tanaka, and Guillaume Varès, and Yi Shang, and Kazuko Fujita, and Yasuharu Ninomiya, and Tetsuo Nakajima, and Kiyomi Eguchi-Kasai, and Mitsuru Nenoi
March 1995, Radiation and environmental biophysics,
Bing Wang, and Kaoru Tanaka, and Guillaume Varès, and Yi Shang, and Kazuko Fujita, and Yasuharu Ninomiya, and Tetsuo Nakajima, and Kiyomi Eguchi-Kasai, and Mitsuru Nenoi
January 2001, Advances in space research : the official journal of the Committee on Space Research (COSPAR),
Bing Wang, and Kaoru Tanaka, and Guillaume Varès, and Yi Shang, and Kazuko Fujita, and Yasuharu Ninomiya, and Tetsuo Nakajima, and Kiyomi Eguchi-Kasai, and Mitsuru Nenoi
June 2022, International journal of molecular sciences,
Bing Wang, and Kaoru Tanaka, and Guillaume Varès, and Yi Shang, and Kazuko Fujita, and Yasuharu Ninomiya, and Tetsuo Nakajima, and Kiyomi Eguchi-Kasai, and Mitsuru Nenoi
January 2001, Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB),
Bing Wang, and Kaoru Tanaka, and Guillaume Varès, and Yi Shang, and Kazuko Fujita, and Yasuharu Ninomiya, and Tetsuo Nakajima, and Kiyomi Eguchi-Kasai, and Mitsuru Nenoi
May 1963, Radiation research,
Copied contents to your clipboard!