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Defining the risks of mesenchymal stromal cell therapy. 2010
Darwin J Prockop, and
Malcolm Brenner, and
Willem E Fibbe, and
Edwin Horwitz, and
Katarina Le Blanc, and
Donald G Phinney, and
Paul J Simmons, and
Luc Sensebe, and
Armand Keating
Texas A&M Health Science College of Medicine, Institute for Regenerative Medicine at Scott & White, Temple, TX 76502, USA. Prockop@medicine.tamhsc.edu
Abstract We address the issue of the potential for malignant transformation of cultured mesenchymal stromal cells (MSC) commonly used in clinical cell-therapy protocols and describe the culture conditions under which tumorigenesis is likely to be an extremely uncommon event.
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