Biomaterial Database

Plasma oxalate and creatinine and oxalate/creatinine clearance ratios in normal subjects and in primary hyperoxaluria. Evidence for renal hyperoxaluria. 1990

G P Kasidas, and S Nemat, and G A Rose

St. Peter's Hospital, London, UK.

Plasma oxalate and creatinine were measured repeatedly in healthy individuals and in 12 patients with type 1 primary hyperoxaluria unresponsive to pyridoxine. The mean ratios were 0.025 (SD 0.006) and 0.120 (SD 0.048), respectively. One patient repeatedly had normal plasma oxalate despite markedly raised urinary oxalate and it seems unlikely that this excess oxalate could have come from the liver. Oxalate/creatinine clearance ratios in the normal group had an overall mean of 0.59 (SD 0.27) in 24 h urine collections and 0.741 (SD 0.297) in repeated short clearance periods. Both renal tubular absorption and secretion of oxalate apparently occurred on different days, but this did not depend upon urinary flow rate. Oxalate/creatinine clearance ratios in type 1 primary hyperoxaluria had a mean of 2.88 (SD 3.11). The raised oxalate/creatinine clearance ratios in the patients were not correlated with either plasma oxalate or creatinine. A few patients showed much higher clearance ratios and in some were sufficiently high to indicate that oxalate was generated and secreted in the kidneys.

UI	MeSH Term	Description	Entries
D006960	Hyperoxaluria, Primary	A genetic disorder characterized by excretion of large amounts of OXALATES in urine; NEPHROLITHIASIS; NEPHROCALCINOSIS; early onset of RENAL FAILURE; and often a generalized deposit of CALCIUM OXALATE. There are subtypes classified by the enzyme defects in glyoxylate metabolism.	Oxaluria, Primary,Primary Hyperoxaluria,Primary Oxalosis,Primary Oxaluria,Hyperoxalurias, Primary,Oxaloses, Primary,Oxalosis, Primary,Oxalurias, Primary,Primary Hyperoxalurias,Primary Oxaloses,Primary Oxalurias
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D008657	Metabolic Clearance Rate	Volume of biological fluid completely cleared of drug metabolites as measured in unit time. Elimination occurs as a result of metabolic processes in the kidney, liver, saliva, sweat, intestine, heart, brain, or other site.	Total Body Clearance Rate,Clearance Rate, Metabolic,Clearance Rates, Metabolic,Metabolic Clearance Rates,Rate, Metabolic Clearance,Rates, Metabolic Clearance
D010070	Oxalates	Derivatives of OXALIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that are derived from the ethanedioic acid structure.	Oxalate,Ethanedioic Acids,Oxalic Acids,Acids, Ethanedioic,Acids, Oxalic
D003404	Creatinine		Creatinine Sulfate Salt,Krebiozen,Salt, Creatinine Sulfate,Sulfate Salt, Creatinine
D004231	Diuresis	An increase in the excretion of URINE. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Diureses
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014462	Ultrafiltration	The separation of particles from a suspension by passage through a filter with very fine pores. In ultrafiltration the separation is accomplished by convective transport; in DIALYSIS separation relies instead upon differential diffusion. Ultrafiltration occurs naturally and is a laboratory procedure. Artificial ultrafiltration of the blood is referred to as HEMOFILTRATION or HEMODIAFILTRATION (if combined with HEMODIALYSIS).
D019815	Oxalic Acid	A strong dicarboxylic acid occurring in many plants and vegetables. It is produced in the body by metabolism of glyoxylic acid or ascorbic acid. It is not metabolized but excreted in the urine. It is used as an analytical reagent and general reducing agent.	Aluminum Oxalate,Ammonium Oxalate,Chromium (2+) Oxalate,Chromium (3+) Oxalate (3:2),Chromium Oxalate,Diammonium Oxalate,Dilithium Oxalate,Dipotassium Oxalate,Disodium Oxalate,Ferric Oxalate,Iron (2+) Oxalate (1:1),Iron (3+) Oxalate,Iron Oxalate,Magnesium Oxalate,Magnesium Oxalate (1:1),Manganese (2+) Oxalate (1:1),Monoammonium Oxalate,Monohydrogen Monopotassium Oxalate,Monopotassium Oxalate,Monosodium Oxalate,Potassium Chromium Oxalate,Potassium Oxalate,Potassium Oxalate (2:1),Sodium Oxalate,Acid, Oxalic,Oxalate, Aluminum,Oxalate, Chromium,Oxalate, Diammonium,Oxalate, Dilithium,Oxalate, Dipotassium,Oxalate, Disodium,Oxalate, Ferric,Oxalate, Iron,Oxalate, Magnesium,Oxalate, Monoammonium,Oxalate, Monohydrogen Monopotassium,Oxalate, Monopotassium,Oxalate, Monosodium,Oxalate, Potassium,Oxalate, Potassium Chromium,Oxalate, Sodium