Biomaterial Database

Darier's disease involving an epidermoid cyst. 1990

H Mittag

Department of Dermatology and Histology, Dermatological Medical Center, Marburg, West Germany.

Histological signs of Darier's disease, including 'corps ronds', 'grains', and acantholytic clefts are demonstrated in the wall of an epidermoid cyst in a patient with Darier's disease of the skin. Possible mechanisms in the development of cyst wall changes are discussed.

UI	MeSH Term	Description	Entries
D007644	Darier Disease	An autosomal dominantly inherited skin disorder characterized by warty malodorous papules that coalesce into plaques. It is caused by mutations in the ATP2A2 gene encoding SERCA2 protein, one of the SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. The condition is similar, clinically and histologically, to BENIGN FAMILIAL PEMPHIGUS, another autosomal dominant skin disorder. Both diseases have defective calcium pumps (CALCIUM-TRANSPORTING ATPASES) and unstable desmosomal adhesion junctions (DESMOSOMES) between KERATINOCYTES.	Acrokeratosis Verruciformis of Hopf,Darier-White Disease,Keratosis Follicularis,Acantholytic Dyskeratotic Epidermal Nevi,Acantholytic Dyskeratotic Epidermal Nevus,Acrokeratosis Verruciformis,Darier's Disease,Hopf Disease,Darier White Disease,Darier-White Diseases,Dariers Disease,Disease, Darier,Disease, Darier's,Disease, Darier-White,Disease, Hopf,Diseases, Darier-White,Diseases, Hopf,Hopf Acrokeratosis Verruciformis,Hopf Diseases,Verruciformis, Acrokeratosis
D008297	Male		Males
D004814	Epidermal Cyst	Intradermal or subcutaneous saclike structure, the wall of which is stratified epithelium containing keratohyalin granules.	Epidermoid Cyst,Pilar Cyst,Sebaceous Cyst,Cyst, Epidermal,Cyst, Epidermoid,Cyst, Pilar,Cyst, Sebaceous,Cysts, Epidermal,Cysts, Epidermoid,Cysts, Pilar,Cysts, Sebaceous,Epidermal Cysts,Epidermoid Cysts,Pilar Cysts,Sebaceous Cysts
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000005	Abdomen	That portion of the body that lies between the THORAX and the PELVIS.	Abdomens
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults