BIOMAT Database Logo BIOMAT Database Logo

Oral clindamycin in the treatment of acute uncomplicated falciparum malaria. 1990

N P Salazar, and M C Saniel, and M H Estoque, and F A Talao, and D G Bustos, and L P Palogan, and A I Gabriel
Research Institute for Tropical Medicine, Department of Health, Alabang, Muntinlupa, Metro Manila, Philippines.

Clinical trials on oral clindamycin as an antimalarial in hospitalized patients and residents of endemic communities were conducted in the Philippines between May 1984 and December 1985. Seven and 9 qualified subjects in hospital were treated with 300 mg (regimen A) and 600 mg (regimen B) respectively, twice daily for 5 days. Eighteen patients seen at a rural health unit were given the lower dosage. On the basis of the 28-day extended in vivo test of WHO, P. falciparum in all but one patient showed susceptibility to the drug as a blood schizontocide hence, the clinical cure of malaria. Side effects were few and self-limiting. Ten other patients on regimen A were cured within the 7- and/or 28-day extended test period. Clindamycin per se is currently one of the few alternatives in the treatment of clinically moderate drug-resistant malaria.

UI MeSH Term Description Entries
D008288 Malaria A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia. Marsh Fever,Plasmodium Infections,Remittent Fever,Infections, Plasmodium,Paludism,Fever, Marsh,Fever, Remittent,Infection, Plasmodium,Plasmodium Infection
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010270 Parasite Egg Count Determination of parasite eggs in feces. Count, Parasite Egg,Counts, Parasite Egg,Egg Count, Parasite,Egg Counts, Parasite,Parasite Egg Counts
D010963 Plasmodium falciparum A species of protozoa that is the causal agent of falciparum malaria (MALARIA, FALCIPARUM). It is most prevalent in the tropics and subtropics. Plasmodium falciparums,falciparums, Plasmodium
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002981 Clindamycin An antibacterial agent that is a semisynthetic analog of LINCOMYCIN. 7-Chloro-7-deoxylincomycin,Chlolincocin,Chlorlincocin,Cleocin,Clindamycin Hydrochloride,Clindamycin Monohydrochloride,Clindamycin Monohydrochloride, Monohydrate,Dalacin C,7 Chloro 7 deoxylincomycin,Hydrochloride, Clindamycin,Monohydrate Clindamycin Monohydrochloride,Monohydrochloride, Clindamycin,Monohydrochloride, Monohydrate Clindamycin
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

N P Salazar, and M C Saniel, and M H Estoque, and F A Talao, and D G Bustos, and L P Palogan, and A I Gabriel
Treatment of acute, uncomplicated, falciparum malaria with oral dihydroartemisinin.
February 1996, Annals of tropical medicine and parasitology,
N P Salazar, and M C Saniel, and M H Estoque, and F A Talao, and D G Bustos, and L P Palogan, and A I Gabriel
Mefloquine versus 3-day oral quinine-clindamycin in uncomplicated imported falciparum malaria.
September 2007, Travel medicine and infectious disease,
N P Salazar, and M C Saniel, and M H Estoque, and F A Talao, and D G Bustos, and L P Palogan, and A I Gabriel
Three-day quinine-clindamycin treatment of uncomplicated falciparum malaria imported from the tropics.
March 2003, Antimicrobial agents and chemotherapy,
N P Salazar, and M C Saniel, and M H Estoque, and F A Talao, and D G Bustos, and L P Palogan, and A I Gabriel
Oral artesunate in the treatment of uncomplicated hyperparasitemic falciparum malaria.
November 1995, The American journal of tropical medicine and hygiene,
N P Salazar, and M C Saniel, and M H Estoque, and F A Talao, and D G Bustos, and L P Palogan, and A I Gabriel
Efficacy of oral pyronaridine for the treatment of acute uncomplicated falciparum malaria in African children.
April 1998, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
N P Salazar, and M C Saniel, and M H Estoque, and F A Talao, and D G Bustos, and L P Palogan, and A I Gabriel
Comparison of oral artemether and mefloquine in acute uncomplicated falciparum malaria.
November 1992, Lancet (London, England),
N P Salazar, and M C Saniel, and M H Estoque, and F A Talao, and D G Bustos, and L P Palogan, and A I Gabriel
Treatment of falciparum malaria with clindamycin.
January 1982, Revista do Instituto de Medicina Tropical de Sao Paulo,
N P Salazar, and M C Saniel, and M H Estoque, and F A Talao, and D G Bustos, and L P Palogan, and A I Gabriel
Cost effective treatment of acute, uncomplicated Plasmodium falciparum malaria.
December 2004, The Journal of the Association of Physicians of India,
N P Salazar, and M C Saniel, and M H Estoque, and F A Talao, and D G Bustos, and L P Palogan, and A I Gabriel
Clindamycin treatment of falciparum malaria in Brazil.
February 1989, The Journal of antimicrobial chemotherapy,
N P Salazar, and M C Saniel, and M H Estoque, and F A Talao, and D G Bustos, and L P Palogan, and A I Gabriel
Quinine plus clindamycin vs artemether-lumefantrine for treatment of uncomplicated falciparum malaria in western Kenya.
June 2022, Malaria journal,
Copied contents to your clipboard!