Biomaterial Database

[Enteropathogenic yersinias: pathogenicity factors and new diagnostic methods]. 1990

J Heesemann

Institut für Hygiene und Mikrobiologie der Universität Würzburg.

A limited number of serotypes of Yersinia enterocolitica and Y. pseudotuberculosis is enteropathogenic for humans. During the last decade molecular biology contributed significantly to the understanding of the pathogenicity of these enteric agents. All human pathogenic Yersiniae harbour a 70-kilobase plasmid which is essential for virulence expression. Presently, thirteen plasmid-encoded polypeptides have been identified. Two of them have been identified as true outer membrane proteins and at least ten are secreted into the culture medium. Plasmid-mediated pathogenic functions are survival in serum, resistance to phagocytosis, cell adhesion, and cytotoxicity. As chromosomal determinants two invasions, one heat-stable enterotoxin and one iron-utilization system have been identified. The contribution of the iron-uptake system to mouse lethality has been clearly demonstrated. The plasmid-encoded proteins have been turned out to be more suitable antigens for serologic diagnosis of yersiniosis (immunoblotting and indirect immunofluorescence) than whole bacterial antigens.

UI	MeSH Term	Description	Entries
D010957	Plasmids	Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.	Episomes,Episome,Plasmid
D004195	Disease Models, Animal	Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	Animal Disease Model,Animal Disease Models,Disease Model, Animal
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001425	Bacterial Outer Membrane Proteins	Proteins isolated from the outer membrane of Gram-negative bacteria.	OMP Proteins,Outer Membrane Proteins, Bacterial,Outer Membrane Lipoproteins, Bacterial
D014774	Virulence	The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.	Pathogenicity
D015008	Yersinia enterocolitica	A species of the genus YERSINIA, isolated from both man and animal. It is a frequent cause of bacterial gastroenteritis in children.	Bacterium enterocoliticum
D015009	Yersinia Infections	Infections with bacteria of the genus YERSINIA.	Yersinia Infection,Infections, Yersinia,Yersinia enterocolitica Infection,Yersiniosis,Infection, Yersinia,Yersinia enterocolitica Infections,Yersinioses
D015011	Yersinia pseudotuberculosis	A human and animal pathogen causing mesenteric lymphadenitis, diarrhea, and bacteremia.
D015012	Yersinia pseudotuberculosis Infections	Infections with bacteria of the species YERSINIA PSEUDOTUBERCULOSIS.	Far East Scarlet-like Fever,Pseudotuberculosis, Pasteurella,Infections, Yersinia pseudotuberculosis,Far East Scarlet like Fever,Pasteurella Pseudotuberculoses,Pasteurella Pseudotuberculosis,Pseudotuberculoses, Pasteurella