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Cyclic AMP dependent protein kinase activity was depressed in whole thymus and spleen as well as isolated splenic lymphocytes from B16 melanoma bearing C57B1/6J mice as compared to control animals. A similar loss of enzyme activity was observed in human peripheral blood lymphocytes from melanoma bearing patients as compared to normal subjects. An unaltered level of activity in the heart of tumor bearing mice suggested some specificity for the lymphoid system. This depressed enzyme activity was the result of a diminished Vmax for cAMP stimulated calf histone phosphorylation. The tumor bearing state in the mouse was also accompanied by a depletion of small lymphocytes from both thymus and spleen and it is hypothesized that the losses of lymphocytes and cAMP dependent protein kinase activity are related.
R A Ortez, and
E M Hersh, and
G A Robison
July 1980,
The Journal of biological chemistry,
R A Ortez, and
E M Hersh, and
G A Robison
January 1995,
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R A Ortez, and
E M Hersh, and
G A Robison
November 1983,
Journal of the Reticuloendothelial Society,
R A Ortez, and
E M Hersh, and
G A Robison
October 1988,
The Biochemical journal,
R A Ortez, and
E M Hersh, and
G A Robison
January 1980,
Postepy higieny i medycyny doswiadczalnej,
R A Ortez, and
E M Hersh, and
G A Robison
January 1991,
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R A Ortez, and
E M Hersh, and
G A Robison
February 1976,
Biochemical and biophysical research communications,
R A Ortez, and
E M Hersh, and
G A Robison
October 1983,
FEBS letters,
R A Ortez, and
E M Hersh, and
G A Robison
February 1979,
Proceedings of the National Academy of Sciences of the United States of America,
R A Ortez, and
E M Hersh, and
G A Robison
April 1976,
Archives internationales de physiologie et de biochimie,
