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Comparison of age-associated changes of c-myc gene methylation in liver between man and mouse. 1990
T Ono, and
S Yamamoto, and
A Kurishita, and
K Yamamoto, and
Y Yamamoto, and
Y Ujeno, and
K Sagisaka, and
Y Fukui, and
M Miyamoto, and
R Tawa
Department of Radiation Research, Tohoku University School of Medicine, Sendai, Japan.
Age-associated changes in DNA methylation of the c-myc gene in liver were compared between humans and mice which have large differences in aging rate. Although the overall methylation profiles of the gene and their age-related changes were found to be similar, the rate of change was much slower in humans than in mice. It suggests that the age-associated alteration of c-myc gene methylation is closely related to biological aging rather than to chronological aging.
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