Biomaterial Database

Serial ultrasonographic observation of bilateral thalami in low birth weight infants with periventricular leukomalacia. 2011

Sumio Fukuda, and Kyoko Yokoi, and Satoshi Suzuki, and Haruo Goto

Department of Pediatrics, Johoku Municipal Hospital, Western Medical Center, 2-15 Kaneda, Kita, Nagoya, Aichi 462-0033, Japan. sumifukuda@yahoo.co.jp

Periventricular leukomalacia is a major form of neuropathology in preterm infants that is associated with adverse motor and cognitive outcomes. The volume of periventricular white matter and corpus callosum has been reported to be diminished in infants with PVL, and the degree of the volume loss is correlated with the severity of neurological impairment. The thalamic index was calculated from the length, height, width of the thalamus, and thalamic volume was calculated using the formula for an ovoid in 62 low birth weight infants with gestational ages of 24-35weeks, 51 control infants (cerebral palsy, 1 case), and 11 infants diagnosed with PVL (cerebral palsy, 7 cases) at postnatal days0-70. The indices of the right thalamus were lower in infants with PVL than in control infants from day0 to day70, and there were significant differences on days 21, 28, 35, 42, 49, 56, 63, and 70. The indices of the left thalamus were lower in infants with PVL than in control infants from day0 to day70, and there were significant differences on days 21, 28, 35, 42, 49, 56, 63, and 70. The results of the present study suggest that the volume of the thalami is reduced and that thalamic injury is associated with white matter lesions in infants with PVL.

UI	MeSH Term	Description	Entries
D007230	Infant, Low Birth Weight	An infant having a birth weight of 2500 gm. (5.5 lb.) or less but INFANT, VERY LOW BIRTH WEIGHT is available for infants having a birth weight of 1500 grams (3.3 lb.) or less.	Low Birth Weight,Low-Birth-Weight Infant,Birth Weight, Low,Birth Weights, Low,Infant, Low-Birth-Weight,Infants, Low-Birth-Weight,Low Birth Weight Infant,Low Birth Weights,Low-Birth-Weight Infants
D007231	Infant, Newborn	An infant during the first 28 days after birth.	Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D007969	Leukomalacia, Periventricular	Degeneration of white matter adjacent to the CEREBRAL VENTRICLES following cerebral hypoxia or BRAIN ISCHEMIA in neonates. The condition primarily affects white matter in the perfusion zone between superficial and deep branches of the MIDDLE CEREBRAL ARTERY. Clinical manifestations include VISION DISORDERS; CEREBRAL PALSY; PARAPLEGIA; SEIZURES; and cognitive disorders. (From Adams et al., Principles of Neurology, 6th ed, p1021; Joynt, Clinical Neurology, 1997, Ch4, pp30-1)	Cystic Periventricular Leukomalacia,Encephalomalacia, Periventricular,Neonatal Cerebral Leukomalacia,Periventricular Leukomalacia,Leucomalacia, Periventricular,Cerebral Leukomalacia, Neonatal,Cerebral Leukomalacias, Neonatal,Cystic Periventricular Leukomalacias,Encephalomalacias, Periventricular,Leucomalacias, Periventricular,Leukomalacia, Cystic Periventricular,Leukomalacia, Neonatal Cerebral,Leukomalacias, Cystic Periventricular,Leukomalacias, Neonatal Cerebral,Leukomalacias, Periventricular,Neonatal Cerebral Leukomalacias,Periventricular Encephalomalacia,Periventricular Encephalomalacias,Periventricular Leucomalacia,Periventricular Leucomalacias,Periventricular Leukomalacia, Cystic,Periventricular Leukomalacias,Periventricular Leukomalacias, Cystic
D008297	Male		Males
D005260	Female		Females
D005865	Gestational Age	The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated from the onset of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization. It is also estimated to begin from fertilization, estrus, coitus, or artificial insemination.	Embryologic Age,Fetal Maturity, Chronologic,Chronologic Fetal Maturity,Fetal Age,Maturity, Chronologic Fetal,Age, Embryologic,Age, Fetal,Age, Gestational,Ages, Embryologic,Ages, Fetal,Ages, Gestational,Embryologic Ages,Fetal Ages,Gestational Ages
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013788	Thalamus	Paired bodies containing mostly GRAY MATTER and forming part of the lateral wall of the THIRD VENTRICLE of the brain.	Thalamencephalon,Thalamencephalons