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Natural product derivatives with bactericidal activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis. 2010
Joshua B Phillips, and
Adrienne E Smith, and
Brian R Kusche, and
Bradley A Bessette, and
P Whitney Swain, and
Stephen C Bergmeier, and
Mark C McMills, and
Dennis L Wright, and
Nigel D Priestley
Department of Chemistry, University of Montana, Missoula, MT 59812, USA.
We have shown that the intentional engineering of a natural product biosynthesis pathway is a useful way to generate stereochemically complex scaffolds for use in the generation of combinatorial libraries that capture the structural features of both natural products and synthetic compounds. Analysis of a prototype library based upon nonactic acid lead to the discovery of triazole-containing nonactic acid analogs, a new structural class of antibiotic that exhibits bactericidal activity against drug resistant, Gram-positive pathogens including Staphylococcus aureus and Enterococcus faecalis.
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Dennis L Wright, and
Nigel D Priestley
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The American journal of medicine,
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Natural product communications,
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June 1985,
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