BIOMAT Database Logo BIOMAT Database Logo

Serum testosterone concentration in male autistic youngsters. 2010

Jan Croonenberghs, and Sarah Van Grieken, and Annick Wauters, and Dirk Van West, and Lucas Brouw, and Michael Maes, and Dirk Deboutte
University Center of Child and Adolescent Psychiatry, University of Antwerp, CAPRI youth, Belgium. jan.croonenberghs@zna.be

OBJECTIVE Research on the biological pathophysiology of autism has found some evidence that alterations in androgenic hormones may play a role in the pathophysiology of that disorder. We studied morning concentrations of serum testosterone in a very homogenic group of postpubertal youngsters with autism and a group of normal controls. METHODS This study examines the serum testosterone concentration on 9 consecutive time points between 08.00 AM and 12.00 AM in 18 high- functioning male youngsters with autism (age 12-18) and 22 healthy volunteers participated in this study. All subjects passed the onset of puberty (Tanner-stage III-IV) and were of the Caucasian race. RESULTS Repeated measures ANOVA revealed a significant time effect, with a decline in the testosterone concentration during the test and time X diagnosis interaction.The total testosterone concentration was significantly lower in the autism group compared to the group of normal controls. CONCLUSIONS The significant decrease in serum testosterone concentration in male youngsters with autism suggest that the turnover of testosterone may take part in the pathophysiology of autism. Suggestions for further research are discussed.

UI MeSH Term Description Entries
D008297 Male Males
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000704 Analysis of Variance A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable. ANOVA,Analysis, Variance,Variance Analysis,Analyses, Variance,Variance Analyses
D001321 Autistic Disorder A disorder beginning in childhood. It is marked by the presence of markedly abnormal or impaired development in social interaction and communication and a markedly restricted repertoire of activity and interest. Manifestations of the disorder vary greatly depending on the developmental level and chronological age of the individual. (DSM-V) Autism, Infantile,Kanner's Syndrome,Autism,Autism, Early Infantile,Disorder, Autistic,Disorders, Autistic,Early Infantile Autism,Infantile Autism,Infantile Autism, Early,Kanner Syndrome,Kanners Syndrome
D013739 Testosterone A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL. 17-beta-Hydroxy-4-Androsten-3-one,17-beta-Hydroxy-8 alpha-4-Androsten-3-one,8-Isotestosterone,AndroGel,Androderm,Andropatch,Androtop,Histerone,Sterotate,Sustanon,Testim,Testoderm,Testolin,Testopel,Testosterone Sulfate,17 beta Hydroxy 4 Androsten 3 one,17 beta Hydroxy 8 alpha 4 Androsten 3 one,8 Isotestosterone
D015992 Body Mass Index An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI Quetelet Index,Quetelet's Index,Index, Body Mass,Index, Quetelet,Quetelets Index
D055815 Young Adult A person between 19 and 24 years of age. Adult, Young,Adults, Young,Young Adults

Related Publications

Jan Croonenberghs, and Sarah Van Grieken, and Annick Wauters, and Dirk Van West, and Lucas Brouw, and Michael Maes, and Dirk Deboutte
[Radioimmunologic determination of serum testosterone concentration in healthy male probands].
January 1985, Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete,
Jan Croonenberghs, and Sarah Van Grieken, and Annick Wauters, and Dirk Van West, and Lucas Brouw, and Michael Maes, and Dirk Deboutte
Decreased serum testosterone concentration in male heroin and methadone addicts.
October 1973, Steroids,
Jan Croonenberghs, and Sarah Van Grieken, and Annick Wauters, and Dirk Van West, and Lucas Brouw, and Michael Maes, and Dirk Deboutte
Daily rhythmicity of serum testosterone concentration in the male laboratory rat.
October 1978, Endocrinology,
Jan Croonenberghs, and Sarah Van Grieken, and Annick Wauters, and Dirk Van West, and Lucas Brouw, and Michael Maes, and Dirk Deboutte
A shifting circannual rhythm in serum testosterone concentration in male laboratory rats.
November 1978, Biology of reproduction,
Jan Croonenberghs, and Sarah Van Grieken, and Annick Wauters, and Dirk Van West, and Lucas Brouw, and Michael Maes, and Dirk Deboutte
Social dominance and serum testosterone concentration in dyads of male Macaca fascicularis.
January 1986, Journal of medical primatology,
Jan Croonenberghs, and Sarah Van Grieken, and Annick Wauters, and Dirk Van West, and Lucas Brouw, and Michael Maes, and Dirk Deboutte
Testosterone serum levels in male psoriatics.
January 1981, Archives of dermatological research,
Jan Croonenberghs, and Sarah Van Grieken, and Annick Wauters, and Dirk Van West, and Lucas Brouw, and Michael Maes, and Dirk Deboutte
[Serum testosterone level in male alcoholics].
January 1975, Vutreshni bolesti,
Jan Croonenberghs, and Sarah Van Grieken, and Annick Wauters, and Dirk Van West, and Lucas Brouw, and Michael Maes, and Dirk Deboutte
Relationship between serum testosterone concentration and patterns of luteinizing hormone secretion in male sheep.
May 1982, Endocrinology,
Jan Croonenberghs, and Sarah Van Grieken, and Annick Wauters, and Dirk Van West, and Lucas Brouw, and Michael Maes, and Dirk Deboutte
Relationship between serum concentration of gonadotropins and testosterone in heat exposed-ageing male rats.
January 1979, Experimental gerontology,
Jan Croonenberghs, and Sarah Van Grieken, and Annick Wauters, and Dirk Van West, and Lucas Brouw, and Michael Maes, and Dirk Deboutte
Cohabitation with a female activates testosterone-dependent social aggression in male rats independently of changes in serum testosterone concentration.
January 1988, Physiology & behavior,
Copied contents to your clipboard!