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We investigated bone tumors of various grades of malignancy as well as tumor-like lesions with regard to proliferation kinetic parameters immunohistologically, autoradiographically, and flow cytophotometrically. Good correlation of the established tumor kinetic parameters with the prognostic expectations of the tumor entities was found. Apart from this, possibilities concerning the differential diagnostic analysis of the proliferation rate in a given tumor and its possible grading as well as the possible practical impact of these modern methods on pre- and/or post-therapeutic monitoring of patients are demonstrated.
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