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Syngeneic transplantation of cultured and functionally characterized neonatal islet into the spleen of streptozotocin diabetic Lewis rats resulted in long time survival up to 200 days and in plasma glucose levels lower than 9 mmol/l. The daily plasma glucose profile of transplanted rats had shown significantly above that of non diabetic control rats. 200 days after transplantation morphologically intact, insulin containing beta-cells were demonstrable in the spleen, thus demonstrating the long-term survival of functioning islet cells. Proliferation of beta-cells was shown in the transplanted islets. In addition, beta-cell clusters were found which derived from pancreatic ductules transplanted together with the isolated islets into the spleen. Mitose were visible within ductular epithelial cells. The proliferative response of islets after intrasplenic transplantation is probably the result of a long-term stimulation by slightly enhanced plasma glucose values of the transplanted acceptors compared to control animals.
F Wohlrab, and
S Schmidt, and
I Kloeting, and
B Wilke, and
L Cossel
June 1992,
Transplantation proceedings,
F Wohlrab, and
S Schmidt, and
I Kloeting, and
B Wilke, and
L Cossel
January 2005,
Journal of investigative surgery : the official journal of the Academy of Surgical Research,
F Wohlrab, and
S Schmidt, and
I Kloeting, and
B Wilke, and
L Cossel
August 1983,
Transplantation,
F Wohlrab, and
S Schmidt, and
I Kloeting, and
B Wilke, and
L Cossel
January 1976,
Zentralblatt fur Chirurgie,
F Wohlrab, and
S Schmidt, and
I Kloeting, and
B Wilke, and
L Cossel
January 1976,
Zentralblatt fur Chirurgie,
F Wohlrab, and
S Schmidt, and
I Kloeting, and
B Wilke, and
L Cossel
January 1977,
Acta physiologica latino americana,
F Wohlrab, and
S Schmidt, and
I Kloeting, and
B Wilke, and
L Cossel
January 1993,
Autoimmunity,
F Wohlrab, and
S Schmidt, and
I Kloeting, and
B Wilke, and
L Cossel
February 1969,
Nature,
F Wohlrab, and
S Schmidt, and
I Kloeting, and
B Wilke, and
L Cossel
March 1977,
Transplantation proceedings,
F Wohlrab, and
S Schmidt, and
I Kloeting, and
B Wilke, and
L Cossel
August 1973,
Nature,
