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A method for the synthesis of an analog of vitamin D3--1alpha-hydroxy vitamin D3 (1alpha-OH D3) from cholesta-4,6-dien-3beta-ol was developed. Biological activity of this compound in the chick organism was measured. The growth stimulating effect of 1alpha-OH D3 and its effect on bone tissue mineralization and serum biochemical parameters (content of calcium, inorganic phosphorus and activity of alkaline phosphatase) were 4--5 times higher than those of vitamin D3 in low doses (19.5--39 pmole/day). In chicks given 1alpha-OH D3 at doses of 39--195 pmole/day most biochemical parameters reached plateau typical of chicks adequately provided with vitamin D. A peculiar feature of 1alpha-OH D3 was a rapid response of the chick organism to/low doses. As early as one hour after intramuscular injection of 650 pmole of 1alpha-OH D3 to D-avitaminotic chicks, the content of calcium-bound protein in the intestinal mucosa and active transport of calcium ions in the inverted intestinal sac increased drastically. It was demonstrated that 1alpha-OH D3 showed antirachitic action, when the physiological reaction to vitamin D3 was inhibited by dietary strontium.
V K Bauman, and
N A Bogoslovskiĭ, and
T A Kisel'nikova, and
M K Shakhova, and
M Iu Valinietse
September 1984,
Chemical & pharmaceutical bulletin,
V K Bauman, and
N A Bogoslovskiĭ, and
T A Kisel'nikova, and
M K Shakhova, and
M Iu Valinietse
December 1982,
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V K Bauman, and
N A Bogoslovskiĭ, and
T A Kisel'nikova, and
M K Shakhova, and
M Iu Valinietse
January 1984,
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V K Bauman, and
N A Bogoslovskiĭ, and
T A Kisel'nikova, and
M K Shakhova, and
M Iu Valinietse
January 1975,
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V K Bauman, and
N A Bogoslovskiĭ, and
T A Kisel'nikova, and
M K Shakhova, and
M Iu Valinietse
January 1975,
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V K Bauman, and
N A Bogoslovskiĭ, and
T A Kisel'nikova, and
M K Shakhova, and
M Iu Valinietse
January 1974,
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V K Bauman, and
N A Bogoslovskiĭ, and
T A Kisel'nikova, and
M K Shakhova, and
M Iu Valinietse
June 1978,
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V K Bauman, and
N A Bogoslovskiĭ, and
T A Kisel'nikova, and
M K Shakhova, and
M Iu Valinietse
April 2012,
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V K Bauman, and
N A Bogoslovskiĭ, and
T A Kisel'nikova, and
M K Shakhova, and
M Iu Valinietse
January 1984,
Mineral and electrolyte metabolism,
V K Bauman, and
N A Bogoslovskiĭ, and
T A Kisel'nikova, and
M K Shakhova, and
M Iu Valinietse
December 1975,
Chemical & pharmaceutical bulletin,
