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A sensitive technique for the electrophoretic characterization of virus-specific antibodies is described. Electrophoretically separated Ig is allowed to diffuse into a virus-antigen containing gel. The antibodies bound to viral antigen are then demonstrated by 125I-labelled rabbit antihuman Ig and autoradiography. Electrophoretically restricted antibodies against measles, rubella, mumps or herpes simplex viruses were demonstrated in some normal sera. The antibody patterns of normal cerebrospinal fluids (CSF) closely resembled those of the matching sera. A selective increase of oligoclonal antibodies was demonstrated in CSF from patients with infection of the central nervous system (CNS) caused by any of the four viruses. We propose that the method may be used to demonstrate local synthesis in the CNS of antibodies against viral or other antigens.
H J Nordal, and
B Vandvik, and
E Norrby
January 1989,
Journal of neurology,
H J Nordal, and
B Vandvik, and
E Norrby
February 1983,
Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology,
H J Nordal, and
B Vandvik, and
E Norrby
April 1982,
Journal of neuroimmunology,
H J Nordal, and
B Vandvik, and
E Norrby
July 1991,
Clinical chemistry,
H J Nordal, and
B Vandvik, and
E Norrby
November 2022,
Diagnostic microbiology and infectious disease,
H J Nordal, and
B Vandvik, and
E Norrby
January 1950,
Beitrage zur Klinik der Tuberkulose und spezifischen Tuberkulose-Forschung,
H J Nordal, and
B Vandvik, and
E Norrby
August 1986,
Journal of neuroimmunology,
H J Nordal, and
B Vandvik, and
E Norrby
February 1987,
Zentralblatt fur Bakteriologie, Mikrobiologie, und Hygiene. Series A, Medical microbiology, infectious diseases, virology, parasitology,
H J Nordal, and
B Vandvik, and
E Norrby
November 1997,
Clinical and diagnostic virology,
H J Nordal, and
B Vandvik, and
E Norrby
January 1964,
Problemy tuberkuleza,
