BIOMAT Database Logo BIOMAT Database Logo

Estimation of skeletal muscle energy metabolism in Machado-Joseph disease using (31)P-MR spectroscopy. 2011

Ichiro Yabe, and Khin K Tha, and Takashi Yokota, and Kazunori Sato, and Hiroyuki Soma, and Asako Takei, and Satoshi Terae, and Koichi Okita, and Hidenao Sasaki
Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.

The aim of this study was to determine if muscle energy metabolism, as measured by (31)P-magnetic resonance spectroscopy (MRS), is a metabolic marker for the efficacy of treatment of Machado-Joseph disease (MJD). We obtained (31)P-MRS in the calf muscle of 8 male patients with MJD and 11 healthy men before, during, and after a 4 minute plantar flexion exercise in a supine position. The data showed that there was a significant difference between the groups in terms of the PCr/(Pi + PCr) ratio at rest (P = 0.03) and the maximum rate of mitochondrial ATP production (V(max)) (P < 0.01). In addition, V(max) was inversely correlated with the scale for the assessment and rating of ataxia score (r = -0.34, P = 0.04). The MJD group also showed a reduction in V(max) over the course of 2 years (P < 0.05). These data suggest that this noninvasive measurement of muscle energy metabolism may represent a surrogate marker for MJD.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009682 Magnetic Resonance Spectroscopy Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING). In Vivo NMR Spectroscopy,MR Spectroscopy,Magnetic Resonance,NMR Spectroscopy,NMR Spectroscopy, In Vivo,Nuclear Magnetic Resonance,Spectroscopy, Magnetic Resonance,Spectroscopy, NMR,Spectroscopy, Nuclear Magnetic Resonance,Magnetic Resonance Spectroscopies,Magnetic Resonance, Nuclear,NMR Spectroscopies,Resonance Spectroscopy, Magnetic,Resonance, Magnetic,Resonance, Nuclear Magnetic,Spectroscopies, NMR,Spectroscopy, MR
D010759 Phosphorus Isotopes Stable phosphorus atoms that have the same atomic number as the element phosphorus, but differ in atomic weight. P-31 is a stable phosphorus isotope. Isotopes, Phosphorus
D011877 Radionuclide Imaging The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph. Gamma Camera Imaging,Radioisotope Scanning,Scanning, Radioisotope,Scintigraphy,Scintiphotography,Imaging, Gamma Camera,Imaging, Radionuclide
D004734 Energy Metabolism The chemical reactions involved in the production and utilization of various forms of energy in cells. Bioenergetics,Energy Expenditure,Bioenergetic,Energy Expenditures,Energy Metabolisms,Expenditure, Energy,Expenditures, Energy,Metabolism, Energy,Metabolisms, Energy
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly

Related Publications

Ichiro Yabe, and Khin K Tha, and Takashi Yokota, and Kazunori Sato, and Hiroyuki Soma, and Asako Takei, and Satoshi Terae, and Koichi Okita, and Hidenao Sasaki
Peripheral arterial occlusive disease: P-31 MR spectroscopy of calf muscle.
May 1990, Radiology,
Ichiro Yabe, and Khin K Tha, and Takashi Yokota, and Kazunori Sato, and Hiroyuki Soma, and Asako Takei, and Satoshi Terae, and Koichi Okita, and Hidenao Sasaki
P-31 MR spectroscopy of skeletal and cardiac muscle metabolism in patients with systemic sclerosis: a multiple case study.
January 1994, Journal of magnetic resonance imaging : JMRI,
Ichiro Yabe, and Khin K Tha, and Takashi Yokota, and Kazunori Sato, and Hiroyuki Soma, and Asako Takei, and Satoshi Terae, and Koichi Okita, and Hidenao Sasaki
Muscle excitability abnormalities in Machado-Joseph disease.
April 2008, Archives of neurology,
Ichiro Yabe, and Khin K Tha, and Takashi Yokota, and Kazunori Sato, and Hiroyuki Soma, and Asako Takei, and Satoshi Terae, and Koichi Okita, and Hidenao Sasaki
Altered phosphate metabolism in myocardial infarction: P-31 MR spectroscopy.
December 1987, Radiology,
Ichiro Yabe, and Khin K Tha, and Takashi Yokota, and Kazunori Sato, and Hiroyuki Soma, and Asako Takei, and Satoshi Terae, and Koichi Okita, and Hidenao Sasaki
Machado-Joseph disease.
January 1995, Clinical neuroscience (New York, N.Y.),
Ichiro Yabe, and Khin K Tha, and Takashi Yokota, and Kazunori Sato, and Hiroyuki Soma, and Asako Takei, and Satoshi Terae, and Koichi Okita, and Hidenao Sasaki
[Machado-Joseph disease].
October 1995, No to shinkei = Brain and nerve,
Ichiro Yabe, and Khin K Tha, and Takashi Yokota, and Kazunori Sato, and Hiroyuki Soma, and Asako Takei, and Satoshi Terae, and Koichi Okita, and Hidenao Sasaki
[Machado Joseph disease].
January 2005, Servir (Lisbon, Portugal),
Ichiro Yabe, and Khin K Tha, and Takashi Yokota, and Kazunori Sato, and Hiroyuki Soma, and Asako Takei, and Satoshi Terae, and Koichi Okita, and Hidenao Sasaki
[Machado-Joseph disease].
January 1999, Ryoikibetsu shokogun shirizu,
Ichiro Yabe, and Khin K Tha, and Takashi Yokota, and Kazunori Sato, and Hiroyuki Soma, and Asako Takei, and Satoshi Terae, and Koichi Okita, and Hidenao Sasaki
[Machado-Joseph disease].
January 2001, Ryoikibetsu shokogun shirizu,
Ichiro Yabe, and Khin K Tha, and Takashi Yokota, and Kazunori Sato, and Hiroyuki Soma, and Asako Takei, and Satoshi Terae, and Koichi Okita, and Hidenao Sasaki
[Machado-Joseph disease: dystonia of the frontal muscle].
May 1988, Rinsho shinkeigaku = Clinical neurology,
Copied contents to your clipboard!