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Hypophysectomy of immature rats results after 5 days in a loss of LH responsiveness of Leydig cells. LH responsiveness can be partly maintained by treatment with FSH for 5 days. When estradiol benzoate was administered together with FSH to hypophysectomized rats the maintenance of LH responsiveness was not observed. The loss in LH responsiveness after hypophysectomy in terms of testosterone production could not be explained by either a change in the amount of Leydig cells present in the Leydig cell preparation or to a higher conversion of testosterone. The LH-stimulated cAMP production in cells from hypophysectomized rats was very low compared to cells from intact rats. There was no difference between cAMP production of Leydig cells from untreated, FSH-treated or FSH plus estradiol benzoate treated hypophysectomized rats. During the first 2 days after hypophysectomy LH responsiveness in both untreated and FSH-treated rats showed a comparable decrease. From day 2 after hypophysectomy LH responsiveness remained at a constant level in cells from rats treated with FSH, but declined further in cells from untreated rats. A single injection of estradiol benzoate to hypophysectomized rats treated with FSH counteracted the effect of FSH on LH responsiveness, but only when estradiol was administered at that time after hypophysectomy, when the effect of FSH on LH responsiveness was clear.
W M van Beurden, and
B Roodnat, and
E Mulder, and
H J van der Molen
December 1981,
Endocrinologia experimentalis,
W M van Beurden, and
B Roodnat, and
E Mulder, and
H J van der Molen
January 1989,
The Journal of endocrinology,
W M van Beurden, and
B Roodnat, and
E Mulder, and
H J van der Molen
March 1982,
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W M van Beurden, and
B Roodnat, and
E Mulder, and
H J van der Molen
July 1979,
Journal of reproduction and fertility,
W M van Beurden, and
B Roodnat, and
E Mulder, and
H J van der Molen
February 1991,
The Journal of steroid biochemistry and molecular biology,
W M van Beurden, and
B Roodnat, and
E Mulder, and
H J van der Molen
August 1976,
Acta endocrinologica,
W M van Beurden, and
B Roodnat, and
E Mulder, and
H J van der Molen
June 1983,
International journal of andrology,
W M van Beurden, and
B Roodnat, and
E Mulder, and
H J van der Molen
August 1976,
Endocrinology,
W M van Beurden, and
B Roodnat, and
E Mulder, and
H J van der Molen
September 1981,
The American journal of physiology,
W M van Beurden, and
B Roodnat, and
E Mulder, and
H J van der Molen
April 1986,
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