-transparent.png){kind=logo}
3-alkylthio-1,2,4-triazine dimers with potent antimalarial activity. 2010
Kung Ban, and
Sandra Duffy, and
Yelena Khakham, and
Vicky M Avery, and
Andrew Hughes, and
Oliver Montagnat, and
Kasiram Katneni, and
Eileen Ryan, and
Jonathan B Baell
Walter & Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
We report on the discovery of 3-alkylthio-1,2,4-triazine dimers that are potently toxic to Plasmodium falciparum, with single digit nanomolar activity, and up to several thousand-fold lower toxicity to mammalian cells. They are equipotent against chloroquine-resistant strains of P. falciparum.
Related Publications
Kung Ban, and
Sandra Duffy, and
Yelena Khakham, and
Vicky M Avery, and
Andrew Hughes, and
Oliver Montagnat, and
Kasiram Katneni, and
Eileen Ryan, and
Jonathan B Baell
January 2018,
European journal of medicinal chemistry,
Kung Ban, and
Sandra Duffy, and
Yelena Khakham, and
Vicky M Avery, and
Andrew Hughes, and
Oliver Montagnat, and
Kasiram Katneni, and
Eileen Ryan, and
Jonathan B Baell
October 2003,
Bioorganic & medicinal chemistry letters,
Kung Ban, and
Sandra Duffy, and
Yelena Khakham, and
Vicky M Avery, and
Andrew Hughes, and
Oliver Montagnat, and
Kasiram Katneni, and
Eileen Ryan, and
Jonathan B Baell
July 2002,
Acta crystallographica. Section C, Crystal structure communications,
Kung Ban, and
Sandra Duffy, and
Yelena Khakham, and
Vicky M Avery, and
Andrew Hughes, and
Oliver Montagnat, and
Kasiram Katneni, and
Eileen Ryan, and
Jonathan B Baell
July 2022,
Archiv der Pharmazie,
Kung Ban, and
Sandra Duffy, and
Yelena Khakham, and
Vicky M Avery, and
Andrew Hughes, and
Oliver Montagnat, and
Kasiram Katneni, and
Eileen Ryan, and
Jonathan B Baell
March 2023,
Pharmaceuticals (Basel, Switzerland),
Kung Ban, and
Sandra Duffy, and
Yelena Khakham, and
Vicky M Avery, and
Andrew Hughes, and
Oliver Montagnat, and
Kasiram Katneni, and
Eileen Ryan, and
Jonathan B Baell
March 1978,
Chemical & pharmaceutical bulletin,
Kung Ban, and
Sandra Duffy, and
Yelena Khakham, and
Vicky M Avery, and
Andrew Hughes, and
Oliver Montagnat, and
Kasiram Katneni, and
Eileen Ryan, and
Jonathan B Baell
June 2013,
Chemistry (Weinheim an der Bergstrasse, Germany),
Kung Ban, and
Sandra Duffy, and
Yelena Khakham, and
Vicky M Avery, and
Andrew Hughes, and
Oliver Montagnat, and
Kasiram Katneni, and
Eileen Ryan, and
Jonathan B Baell
March 2007,
Bioorganic & medicinal chemistry letters,
Kung Ban, and
Sandra Duffy, and
Yelena Khakham, and
Vicky M Avery, and
Andrew Hughes, and
Oliver Montagnat, and
Kasiram Katneni, and
Eileen Ryan, and
Jonathan B Baell
January 2010,
Acta crystallographica. Section E, Structure reports online,
Kung Ban, and
Sandra Duffy, and
Yelena Khakham, and
Vicky M Avery, and
Andrew Hughes, and
Oliver Montagnat, and
Kasiram Katneni, and
Eileen Ryan, and
Jonathan B Baell
August 2016,
Journal of medicinal chemistry,
