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The effects of histamine on endogenous prostaglandins and on the damage caused by 0.6 N HCl were tested in rat gastric mucosa. The damage was assessed both macroscopically and microscopically. Histamine increased the prostaglandin E2 level in vivo and stimulated the synthesis of prostaglandin E2 and 6-keto-prostaglandin F1 alpha in vitro. These effects of histamine were inhibited by treatment with cimetidine beforehand. Histamine inhibited both the gross visible mucosal damage and deep necrosis caused by the intragastric instillation of 0.6 N HCl. This effect was overcome by cimetidine or indomethacin, but not by diphenhydramine. These results suggest that histamine stimulates prostaglandin synthesis and induces cytoprotection in rat gastric mucosa, perhaps with the involvement of the H2 receptor.
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H Satoh, and
T Fukuda, and
H Sakuma, and
K Kobayashi, and
K Kitada, and
H Nakamura, and
K Kobayashi
January 1987,
Advances in prostaglandin, thromboxane, and leukotriene research,
T Arakawa, and
H Satoh, and
T Fukuda, and
H Sakuma, and
K Kobayashi, and
K Kitada, and
H Nakamura, and
K Kobayashi
April 1979,
Acta hepato-gastroenterologica,
T Arakawa, and
H Satoh, and
T Fukuda, and
H Sakuma, and
K Kobayashi, and
K Kitada, and
H Nakamura, and
K Kobayashi
January 1993,
Journal of clinical gastroenterology,
T Arakawa, and
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K Kitada, and
H Nakamura, and
K Kobayashi
January 1991,
Acta medica Hungarica,
T Arakawa, and
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December 1995,
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society,
T Arakawa, and
H Satoh, and
T Fukuda, and
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H Nakamura, and
K Kobayashi
January 1978,
Gastroenterology,
T Arakawa, and
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H Sakuma, and
K Kobayashi, and
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H Nakamura, and
K Kobayashi
June 1997,
Pharmacology,
T Arakawa, and
H Satoh, and
T Fukuda, and
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K Kobayashi, and
K Kitada, and
H Nakamura, and
K Kobayashi
January 1967,
Federation proceedings,
T Arakawa, and
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K Kobayashi, and
K Kitada, and
H Nakamura, and
K Kobayashi
January 1994,
Journal of gastroenterology and hepatology,
T Arakawa, and
H Satoh, and
T Fukuda, and
H Sakuma, and
K Kobayashi, and
K Kitada, and
H Nakamura, and
K Kobayashi
November 1994,
Canadian journal of physiology and pharmacology,
