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Anti-influenza virus compound from Streptomyces sp. RI18. 2010
Motoki Takagi, and
Keiichiro Motohashi, and
Aya Nagai, and
Miho Izumikawa, and
Masahiro Tanaka, and
Shinichiro Fuse, and
Takayuki Doi, and
Keiichiro Iwase, and
Atsushi Kawaguchi, and
Kyosuke Nagata, and
Takashi Takahashi, and
Kazuo Shin-ya
Biomedicinal Information Research Center (BIRC), Japan Biological Informatics Consortium (JBIC), 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan. motoki-takagi@aist.go.jp
Screening for anti-influenza virus activity in compounds isolated from Streptomyces sp. RI18, which was isolated using the membrane filter method, uncovered a novel compound, JBIR-68 (1), which contains a unique skeleton. Its structure was established by extensive NMR and MS analyses. In addition, 1 was synthesized to confirm the configuration of its sugar moiety. Compound 1 inhibited influenza virus growth in plaque assays.
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